Guinovart, caterina;
Bassat, quique;
Sigaúque, betuel;
Aide, pedro;
Sacarlal, jahit;
Nhampossa, tacilta;
Bardají, azucena;
Nhacolo, ariel;
Macete, eusébio;
Mandomando, inácio;
Aponte, john J;
Menéndez, clara;
Alonso, pedro L.
Background: Malaria represents a huge burden for the health care services across Africa. Describing malaria attending health services contributes to quantify the burden and describe the epidemiology and clinical presentation.
Methods: Retrospective analysis of data collected through the Manhiça morbidit...
Malaria, Falciparum/diagnosis,
Plasmodium falciparum/isolation & purification,
Rural Health Services/statistics & numerical data,
Malaria, Falciparum/therapy,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/prevention & control,
Ambulatory Care Information Systems/statistics & numerical data,
Risk Factors,
Mozambique/epidemiology
Bardají, azucena;
Sigauque, betuel;
Bruni, mlaia;
Romagosa, cleofé;
Sanz, sergi;
Mabunda, samuel;
Mandomando, inacio;
Aponte, john;
Sevene, esperança;
Alonso, pedro L;
Menéndez, clara.
Background: There is a widespread notion, based on limited information, that in areas of stable malaria transmission most pregnant women with Plasmodium falciparum infection are asymptomatic. This study aim to characterize the clinical presentation of malaria in African pregnant women and to evaluate the...
Aponte , john J;
Aide, pedro;
Renom, montse;
Mandomando, Inacio;
Bassat, quique;
Sacarlal, jahit;
Manaca, nelia;
Lafuente, sarah;
Barbosa, arnoldo;
Leach, amanda;
Vekemans , johan;
Lievens, marc;
Sigauque, betuel;
Dubois, marie-claude;
Demoitié, marie ange;
Sillman, marla;
McNeil, john G;
Savarese, barbara;
Macete, eusebio;
Cohen, joe;
Ballou, W ripley;
Alonso, pedro L.
Background: Malaria remains a leading global health problem that requires the improved use of existing interventions and the accelerated development of new control methods. We aimed to assess the safety, immunogenicity, and initial efficacy of the malaria vaccine RTS,S/AS02D in infants in Africa. Methods...
Background: Indoor residual spraying (IRS) has again become popular for malaria control in Africa. This combined with the affirmation by WHO that DDT is appropriate for use in the absence of longer lasting insecticide formulations in some malaria endemic settings, has resulted in an increase in IRS with ...
Environmental Monitoring,
Malaria/prevention & control,
Fumigation/methods,
Fumigation/economics,
Insecticide Resistance,
Population,
Insect Vectors,
Mosquito Control/economics,
Mosquito Control/methods,
Mozambique,
Anopheles
Menendez, clara;
Schellenberg, david;
Macete, eusebio;
Aide, pedro;
Kahigwa, elizeus;
Sanz, sergi;
Aponte, john J;
Sacarlal, jahit;
Mshinda, hassan;
Tanner, marcel;
Alonso, pedro L.
Background: Intermittent preventive treatment (IPTi) with sulphadoxine-pyrimethamine (SP) in infants resulted in different estimates of clinical malaria protection in two trials that used the same protocol in Ifakara, Tanzania, and Manhiça, Mozambique. Understanding the reasons for the discrepant result...
Marijon, Eloi;
Ou, Phalla;
Celermajer, David S;
Ferreira, Beatriz;
Mocumbi, Ana Olga;
Jani, Dinesh;
Paquet, Christophe;
Jacob, Sophie;
Sidi, Daniel;
Jouven, Xavier.
Background: Epidemiologic studies of the prevalence of rheumatic heart disease have used clinical screening with echocardiographic confirmation of suspected cases. We hypothesized that echocardiographic screening of all surveyed children would show a significantly higher prevalence of rheumatic heart dis...
Macete, E;
Aponte, J. J;
Guinovart, C;
Sacarlal, J;
Ofori-Anyinam, O;
Mandomando, I;
Espasa, M;
Bevilacqua, C;
Leach, A;
Dubois, M C;
Heppner, D G;
Tello, L;
Milman, J;
Cohen, J;
Dubovsky, F;
Tornieporth, N;
Thompson, R;
Alonso, P. L.
The development of a malaria vaccine remains a public health priority for sub-Saharan Africa. RTS,S/AS02A candidate malaria vaccine has been shown to be safe and immunogenic in previous studies in adults and staggered dose-escalation studies in children in The Gambia. However, genetic features and the in...
Romagosa, cleofe;
Ordi, jaume;
Saute, francisco;
Quinto, llorenc;
Machungo, fernanda;
Ismail, mamudo R;
Carrilho, carla;
Osman, nafissa;
Alonso, pedro L;
Menendez, clara.
Objective: To evaluate the impact of malaria on maternal death through the analysis of the seasonal variations of crude and malaria-specific maternal mortality rates. Methods: All maternal deaths and live births occurring at Maputo Central Hospital, located in an urban area, between January 2001 and Dece...
Objective: To describe attitudes to the expanded programme on immunization (EPI) and intermittent preventive treatment in infants (IPTi), and perceptions of the relationship between them. In particular, whether the introduction of IPTi negatively affects community attitudes to, or use of, EPI; or, conver...
Health Knowledge, Attitudes, Practice,
Caregivers/psychology,
Delivery of Health Care/methods,
Delivery of Health Care/organization & administration,
Hematologic Tests/psychology,
Immunization/psychology,
Malaria Vaccines/therapeutic use,
Immunization Programs/organization & administration,
Malaria, Falciparum/psychology,
Patient Acceptance of Health Care/psychology,
Mozambique/epidemiology
Quinto, llorenc;
Aponte, john J;
Sacarlal, jahit;
Espasa, mateu;
Aide, pedro;
Mandomando, inacio;
Guinovart, caterina;
Macete, eusebio;
Navia, margarita M;
Thompson, ricardo;
Menendez, clara;
Alonso, pedro L.
Introduction: The reference intervals of haematological and biochemical indices currently used in Africa are derived from data collected from populations living in industrialized countries. Few studies have been performed in Africa questioning the validity of these values when applied to local African po...
