Objective (of this study is): To describe the radiographic pattern of PTB in HIV-1 seropositive and seronegative patients and to study the relationship between radiographic pattern and degree of immunosuppression based on CD4 counts. Design: Cross-sectional; descriptive study. Setting: TB tratment centre...
Two randomised controlled trials of sexually transmitted disease (STD) treatment for the prevention of HIV-1 infection; in Mwanza; Tanzania and Rakai; Uganda; unexpectedly produced contrasting results. A decrease in population HIV-1 incidence was associated with improved STD case management in Mwanza; bu...
Infection with streptococcus pneumoniae is a frequent and serious problem for HIV-immunosuppressed adults. Vaccination is recommended in the USA and europe; but there are no prospective data that show vaccine efficacy. Methods: 1392 (937 female) HIV-1-infected adults in Entebbe; Uganda; were enrolled. 69...
Despite growing international pressure to provide HIV-1 treatment to less-developed countries; potential demographic and epidemiological impacts have yet to be characterised. We modelled the future impact of antiretroviral use in south Africa from 2000 to 2005. methods: We produced a population projectio...
An association between HIV-1 and malaria is expected in theory; but has not been convincingly shown in practice. We studied the effects of HIV-1 infection and advancing immunosuppression on falciparum parasitaemia and clinical malaria. Methods: HIV-positive and HIV-negative adults selected from a populat...
To examine the effect of HIV infection old infectiousness of TB. Design: Cross-sectional prevalence study of household contacts to smear positive TB patients. Methods: HIV-infected and non-infected index TB cases with sputum smear positive TB; were enrolled from a major TB clinic at Mulago Hospital in Ka...
Setting: National Tuberculosis (TB) Treatment Centre; Mulago Hospital and Joint Clinical Research Centre; Kampala; Uganda. Objective: To compare the quantitative sputum bacillary load between TB patients infected with the human immunodeficiency virus (HIV) and those non-infected; during treatment with st...
