Nhama, Abel;
Bassat 1, Quique;
Enosse, Sónia;
Nhacolo, Arsenio;
Mutemba, Rosália;
Carvalho, Eva;
Naueia, Eva;
Sevene, Esperança;
Guinovart, Caterina;
Warsame, Marian;
Sanz, Sergi;
Mussa, Abdul;
Matsinhe, Graça;
Alonso, Pedro;
Tiago, Armindo;
Macete, Eusebio.
Background: Mozambique adopted artemisinin-based combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria in the year 2006, and since 2009 artemether-lumefantrine (AL) and artesunateamodiaquine (ASAQ) have been proposed as alternative first-line treatments. A multicentre...
Amodiaquine/therapeutic use,
Antimalarials/adverse effects,
Antimalarials/therapeutic use,
Artemether, Lumefantrine Drug Combination,
Artemisinins/adverse effects,
Artemisinins/therapeutic use,
Drug Combinations,
Ethanolamines/adverse effects,
Ethanolamines/therapeutic use,
Artesunate/therapeutic use,
Fluorenes/therapeutic use,
Malaria, Falciparum/drug therapy,
Malaria, Falciparum/epidemiology,
Artemether, Lumefantrine Drug Combination/therapeutic use,
Mozambique/epidemiology
Nhama, Abel;
Bassat, Quique;
Enosse, Sónia;
Nhacolo, Arsenio;
Mutemba, Rosália;
Carvalho, Eva;
Naueia, Eva;
Sevene, Esperança;
Guinovart, Caterina;
Warsame, Marian;
Sanz, Sergi;
Mussa, Abdul;
Matsinhe, Graça;
Alonso, Pedro;
Tiago, Armindo;
Macete, Eusebio.
Background: Mozambique adopted artemisinin-based combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria in the year 2006, and since 2009 artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) have been proposed as alternative first-line treatments. A multicentr...
Amodiaquine/adverse effects,
Amodiaquine/therapeutic use,
Antimalarials/adverse effects,
Antimalarials/therapeutic use,
Artemether, Lumefantrine Drug Combination,
Artemisinins/adverse effects,
Artemisinins/therapeutic use,
Drug Combinations,
Ethanolamines/adverse effects,
Ethanolamines/therapeutic use,
Fluorenes/adverse effects,
Fluorenes/therapeutic use,
Kaplan-Meier Estimate,
Malaria, Falciparum/drug therapy,
Malaria, Falciparum/epidemiology,
Treatment Outcome,
Mozambique/epidemiology
Nhabomba, augusto J;
Guinovart, caterina;
Dobaño, carlota;
Alonso, pedro L;
Chitnis, chetan E;
Mayor, alfredo;
Aponte, john J;
Bassat, quique;
Rodríguez, mauricio H;
Barbosa, arnoldo;
Aguila, ruth;
Cisteró, pau;
Quintó, llorenç;
Manaca, maria N;
Jiménez, alfons.
Background: The impact of the age of first Plasmodium falciparum infection on the rate of acquisition of immunity to malaria and on the immune correlates of protection has proven difficult to elucidate. A randomized, double-blind, placebo-controlled trial using monthly chemoprophylaxis with sulphadoxine-...
Malaria, Falciparum/immunology,
Mozambique/epidemiology,
Pyrimethamine/therapeutic use,
Sulfadoxine/therapeutic use,
Adaptive Immunity,
Antigens, Protozoan/immunology,
Environmental Exposure,
Malaria, Falciparum/prevention & control,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/parasitology,
Enzyme-Linked Immunosorbent Assay,
Erythrocytes/parasitology,
Erythrocytes/immunology,
Chemoprevention
Nhampossa, Tacilta;
Mandomando, Inacio;
Acacio, Sozinho;
Nhalungo, Delino;
Sacoor, Charfudin;
Nhacolo, Ariel;
Macete, Eusebio;
Nhabanga, Arnaldo;
Quintó, Llorenç;
Kotloff, Karen;
Levine, Myron M;
Nasrin, Dilruba;
Farag, Tamer;
Bassat, Quique;
Alonso, Pedro.
In the predominantly rural Manhiça district, in southern Mozambique, diarrhea is one of the leading causes of death among children under 5 years. Caretakers randomly selected from the Demographic Surveillance Database were invited to participate in a community-based survey on use of healthcare services ...
Caregivers/psychology,
Diarrhea, Infantile/epidemiology,
Health Knowledge, Attitudes, Practice,
Health Surveys,
Patient Acceptance of Health Care/psychology,
Patient Acceptance of Health Care/statistics & numerical data,
Prevalence,
Primary Health Care/statistics & numerical data,
Risk Factors,
Rural Population,
Severity of Illness Index,
Mozambique/epidemiology
Stigma has been implicated in poor outcomes of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) care. Reducing stigma is important for HIV prevention and long-term treatment success. Although stigma reduction interventions are conducted in Mozambique, little is known about the...
Acquired Immunodeficiency Syndrome/epidemiology,
Acquired Immunodeficiency Syndrome/psychology,
Anti-HIV Agents/therapeutic use,
Consensus,
HIV Seropositivity/psychology,
HIV Seropositivity/epidemiology,
Social Stigma,
Health Services Needs and Demand,
Health Knowledge, Attitudes, Practice,
Health Personnel,
Mozambique/epidemiology
Background: Plasmodium falciparum and HIV-1 infection cause substantial morbidity and mortality in sub-Saharan Africa. Increasing evidence suggests these two pathogens interact negatively when infecting the same individual.
Methods: A cross-sectional study among HIV-1 infected and uninfected populations...
HIV prevalence rates in Zambézia Province were estimated to be 12.6% in 2009. A number of educational campaigns have been aimed at improving HIV transmission and prevention knowledge among community members in an effort to reduce infection rates. These campaigns have also encouraged people to seek healt...
Anti-HIV Agents/therapeutic use,
Mozambique/epidemiology,
Africa,
Residence Characteristics,
Delivery of Health Care,
HIV Infections/epidemiology,
HIV Infections/psychology,
HIV Infections/therapy,
Health Knowledge, Attitudes, Practice,
Medicine, African Traditional,
Patient Acceptance of Health Care/psychology,
Patient Acceptance of Health Care/statistics & numerical data,
Rural Population/statistics & numerical data,
Sexual Partners/psychology
Cliff, Julie;
Lewin, Simon;
Woelk, Godfrey;
Fernandes, Benedita;
Mariano, Alda;
Sevene, Esperança;
Daniels, Karen;
Matinhure, Sheillah;
Oxman, Andrew;
Lavis, John.
Introduction Indoor residual spraying (IRS) and insecticide-treated nets (ITNs), two principal malaria control strategies, are similar in cost and efficacy. We aimed to describe recent policy development regarding their use in Mozambique, South Africa and Zimbabwe.
Methods Using a qualitative case study ...
Insect Vectors,
Insecticide-Treated Bednets,
Insecticides,
Malaria,
Mosquito Control,
Policy Making,
Qualitative Research,
Mozambique/epidemiology,
South Africa,
Zimbabwe,
Malaria/transmission,
Malaria/prevention & control
Namiche, denise;
Bardaji, açucena;
Lahuerta, maria;
Berenguera, ana;
Mandomando, inácio;
Sanz, sergio;
Aponte, Joao j;
Sigouque, betuel;
Alonso, pedro l;
Menéndez, clara.
We assessed the effect of maternal human immunodeficiency virus (HIV) infection on birth outcomes and infant survival in rural Mozambique. Pregnant women attending the antenatal clinic were recruited. These women and their infants were followed-up for one year. Birth outcomes were assessed at delivery an...
Adolescent,
Adult,
HIV-1,
Infant Mortality,
Mozambique/epidemiology,
Viral Load,
Infant,
Rural Population,
Pregnancy,
Young Adult,
Infectious Disease Transmission, Vertical
Hutton, guy;
Schellenberg, david;
Tediosi, fabrizio;
Macete, eusebio;
Kahigwa, elizeus;
Sigauque, betuel;
Mas, xavier;
Trapero, marta;
Tanner, marcel;
Menendez, clara;
Alonso, pedro;
Trilla, antoni.
Objective: To estimate the cost-effectiveness of malaria intermittent preventive treatment in infants (IPTi) using sulfadoxine-pyrimethamine (SP). Methods: In two previous IPTi trials in Ifakara (United Republic of Tanzania) and Manhiça (Mozambique), SP was administered three times to infants before 9 m...
