In late 2002, the health authorities of Mozambique implemented sulphadoxine-pyrimethamine (SP)/amodiaquine (AQ) as first-line treatment against uncomplicated falciparum malaria. In 2004, this has been altered to SP/artesunate in line with WHO recommendations of using Artemisinin Combination Therapies (AC...
Pyrimethamine/pharmacology,
Protozoan Proteins/genetics,
Malaria, Falciparum/epidemiology,
d0161330,
d0138120,
Mozambique/epidemiology,
Ligases,
Drug Combinations,
Drug Resistance/genetics,
Ezetimibe, Simvastatin Drug Combination/therapeutic use,
Pyrimethamine/supply & distribution,
Pharmaceutical Preparations,
Haplotypes/genetics,
Malaria, Falciparum/therapy,
Malaria, Falciparum/parasitology,
Plasmodium falciparum/radiation effects,
Plasmodium falciparum/isolation & purification,
Protozoan Proteins/standards,
Sulfadoxine/pharmacology
Bassat, quique;
Guinovart, caterina;
Sigaúque, betuel;
Aide, pedro;
Sacarlal, jahit;
Nhampossa, tacilta;
Bardají, azucena;
Nhacolo, ariel 2,;
Macete, eusébio;
Mandomando, inácio;
Aponte, john J;
Alonso, pedro L;
Menéndez, clara.
Background: Characterization of severe malaria cases on arrival to hospital may lead to early recognition and improved management. Minimum community based-incidence rates (MCBIRs) complement hospital data, describing the malaria burden in the community. Methods: A retrospective analysis of all admitted m...
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/mortality,
Malaria, Falciparum/physiopathology,
Malaria, Falciparum/therapy,
Multivariate Analysis,
Plasmodium falciparum/isolation & purification,
Mozambique/epidemiology,
Logistic Models,
Risk Factors,
Seasons,
Hospitalization
Guinovart, caterina;
Bassat, quique;
Sigaúque, betuel;
Aide, pedro;
Sacarlal, jahit;
Nhampossa, tacilta;
Bardají, azucena;
Nhacolo, ariel;
Macete, eusébio;
Mandomando, inácio;
Aponte, john J;
Menéndez, clara;
Alonso, pedro L.
Background: Malaria represents a huge burden for the health care services across Africa. Describing malaria attending health services contributes to quantify the burden and describe the epidemiology and clinical presentation.
Methods: Retrospective analysis of data collected through the Manhiça morbidit...
Malaria, Falciparum/diagnosis,
Plasmodium falciparum/isolation & purification,
Rural Health Services/statistics & numerical data,
Malaria, Falciparum/therapy,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/prevention & control,
Ambulatory Care Information Systems/statistics & numerical data,
Risk Factors,
Mozambique/epidemiology
Macete, E;
Aponte, J. J;
Guinovart, C;
Sacarlal, J;
Ofori-Anyinam, O;
Mandomando, I;
Espasa, M;
Bevilacqua, C;
Leach, A;
Dubois, M C;
Heppner, D G;
Tello, L;
Milman, J;
Cohen, J;
Dubovsky, F;
Tornieporth, N;
Thompson, R;
Alonso, P. L.
The development of a malaria vaccine remains a public health priority for sub-Saharan Africa. RTS,S/AS02A candidate malaria vaccine has been shown to be safe and immunogenic in previous studies in adults and staggered dose-escalation studies in children in The Gambia. However, genetic features and the in...
Objective: To describe attitudes to the expanded programme on immunization (EPI) and intermittent preventive treatment in infants (IPTi), and perceptions of the relationship between them. In particular, whether the introduction of IPTi negatively affects community attitudes to, or use of, EPI; or, conver...
Health Knowledge, Attitudes, Practice,
Caregivers/psychology,
Delivery of Health Care/methods,
Delivery of Health Care/organization & administration,
Hematologic Tests/psychology,
Immunization/psychology,
Malaria Vaccines/therapeutic use,
Immunization Programs/organization & administration,
Malaria, Falciparum/psychology,
Patient Acceptance of Health Care/psychology,
Mozambique/epidemiology
Quinto, llorenç;
Aponte, joão J;
Menéndez, clara;
Sacarlal, jahit;
Assessor, pedro;
Espasa, mateus;
Mandomando, inácio;
Guinovart, caterina;
Macete, Eusébio;
Hirt, rosmarie;
Urassa, honorathy;
Navia, margarita M;
Alonso, pedro L;
Thompson, ricardo.
Introduction: Anaemia is the most frequent haematological disorder in childhood. The notion that defines naemia does not change throughout life, although parameters used for its evaluation show significant variations during childhood. Haematocrit (Hct) (%) is usually defined as three times the value of h...
Roca, A;
Sigaúque, B;
Quintó, Ll;
Mandomando, L;
Vallès, X;
Espasa, M;
Abacassamo, F;
Sacarlal, J;
Macete, E;
Nhacolo, A;
Levine, M;
Alonso, P.
Objectivos Estimar a incidência e as características epidemiológicas do pneumococo invasivodoença (DPI) em crianças de <5 anos de idade residentes em uma área rural do sul de Moçambique.Métodos Como parte do manejo clínico de crianças internadas em Manhiçum Hospital Distrital,A vigilância pr...
Meningitis, Pneumococcal,
Meningitis, Pneumococcal/epidemiology,
Chloramphenicol/therapeutic use,
Rural Population,
Mozambique/epidemiology,
Population Surveillance/methods,
Pneumococcal Infections/epidemiology,
Pneumonia/chemically induced,
Rural Health,
Anti-Infective Agents/therapeutic use
Alonso, pedro L;
Sacarlal, jahit;
Aponte, john J;
Leach, amanda;
Macete, eusebio;
Milman, jessica;
Mandomando, inacio;
Spiessens, Bart;
Guinovart, caterina;
Espasa, mateu;
Bassat, quique;
Aide, pedro;
Anyinam, opokua Ofori;
Navia, margarita M;
Corachan, sabine.
Background: Development of an effective malaria vaccine could greatly contribute to disease control. RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on Plasmodium falciparum circumsporozoite surface antigen. We aimed to assess vaccine efficacy, immunogenicity, and safety in young African childr...
We estimated the incidence of clinical malaria episodes by weekly home-based active case detection between December 1996 and July 1999 in 2 groups of children in Manhiça district in southern Mozambique. Cohort 1 comprised a random sample of children aged <10 years at recruitment and cohort 2 comprised n...
A total of 2057 children aged <10 years were selected at random from a demographic surveillance system and enrolled in 4 malariometric cross-sectional surveys in different seasons in Manhiça district in southern Mozambique. Plasmodium falciparum accounted for 90% of all malaria infections and the preval...
