Insight into DNA Gyrase inhibition using quantitative structure-Activity relationships and structure-based drug design approaches
Batna Journal of Medical Sciences (online); 9 (2), 2022
The emergence of certain bacterial strains resistant to antibiotics has become a major public health problem, hence the need to develop new antibiotic molecules. Bacterial DNA gyrase, a type II DNA topoisomerase found in all bacteria is a proven target for antibacterial chemotherapy. Our objective is des...