AIM

Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition

Corey, lawrence; Gilbert, peter B; Juraska, michal; Montefiori, david C; Morris, lynn.

N. Engl. j. med; 384 (11), 2021

BACKGROUND—Whether a broadly neutralizing antibody (bnAb) can be used to prevent human immunodeficiency virus type 1 (HIV-1) acquisition is unclear. METHODS—We enrolled at-risk cisgender men and transgender persons in the Americas and Europe in the HVTN 704/HPTN 085 trial and at-risk women in sub-Sah...

Africa South of the Sahara, Antibodies, Monoclonal, Broadly Neutralizing Antibodies, Double-Blind Method, HIV Antibodies, HIV Infections, Mozambique

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Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Infected Women Receiving Cotrimoxazole Prophylaxis: A Multicenter Randomized Placebo-Controlled Trial

PloS med; 14 (160), 2014

Background: Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended for malaria prevention in HIV-negative pregnant women, but it is contraindicated in HIV-infected women taking daily cotrimoxazole prophylaxis (CTXp) because of potential added risk of adve...

Antimalarials/administration & dosage, Double-Blind Method, Follow-Up Studies, HIV Infections/diagnosis, HIV Infections/drug therapy, HIV Infections/epidemiology, Infectious Disease Transmission, Vertical/prevention & control, Malaria/diagnosis, Malaria/epidemiology, Malaria/prevention & control, Mefloquine/administration & dosage, Pregnancy Complications, Infectious/diagnosis, Pregnancy Complications, Infectious/epidemiology, Pregnancy Complications, Infectious/prevention & control, Pregnancy Complications, Parasitic/diagnosis, Pregnancy Complications, Parasitic/epidemiology, Pregnancy Complications, Parasitic/prevention & control, Pregnancy Outcome, Mozambique/epidemiology, Tanzania/epidemiology, Kenya/epidemiology, Trimethoprim, Sulfamethoxazole Drug Combination/administration & dosage

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