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Assessing Performance of HRP2 Antigen Detection for Malaria Diagnosis in Mozambique

Plucinski, Mateusz M; Candrinho, Baltazar; Dimene, Mercia; Colborn, James; Lu, Austin; Nace, Doug; Zulliger, Rose; Rogier, Eric.
J. clin. microbiol; 57 (9), 2019
Rapid diagnostic tests (RDTs) that detect the Plasmodium falciparum-specific histidine-rich protein 2 (PfHRP2) antigen are the primary methods for malaria diagnosis in Mozambique. However, these tests do not detect infections with non-falciparum malaria or Pfhrp2- and Pfhrp3-deleted P. falciparum parasit...
Antigens, Protozoan/blood, Fructose-Bisphosphate Aldolase/blood, Immunoassay/methods, L-Lactate Dehydrogenase/blood, Plasmodium falciparum/genetics, Plasmodium falciparum/isolation & purification, Malaria, Falciparum/immunology, Malaria/diagnosis
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Prozone in malaria rapid diagnostics tests: how many cases are missed?

Gillet, philippe; Annelies, Scheirlinck; Stokx, jocelijn; Weggheleire, anja de; Chaúque, hélder s; Canhanga, oreana D J V; Tadeu, benvindo t; Mosse, carla d d; Tiago, armindo; Mabunda, Samuel; Bruggeman, cathrien; Bottieau, emmanuel; Jacobs, jan.
Malar. j. (Online); 10 (166), 2011
Background: Prozone means false-negative or false-low results in antigen-antibody reactions, due to an excess of either antigen or antibody. The present study prospectively assessed its frequency for malaria rapid diagnostic tests (RDTs) and Plasmodium falciparum samples in an endemic field setting. Met...
Clinical Laboratory Techniques/methods, Immunoassay/methods, Diagnostic Errors/statistics & numerical data, Malaria, Falciparum/diagnosis, Plasmodium falciparum/immunology, Mozambique, Middle Aged
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