Fombah, augustin E;
Chen, haily;
Quinto, llorenç;
Kyei, kwabena owusu;
Gonzalez, raquel;
Williams, julian;
Berne, mireia lLach;
Wassenaar, myrte;
Jalloh, abubakarr;
Sunders, joe-henry C;
Ramirez, maximo;
Cobo, cesc bertran;
Saute, francisco;
Ekouevi, didier K;
Briand, valérie;
Kamara, anitta R Y;
Sesay, tom;
Samai, mohamed;
Menendez, clara.
Background: Intermittent Preventive Treatment of malaria in infants (IPTi) is a malaria control strategy consisting of the administration of an anti-malarial drug alongside routine immunizations. So far, this is being implemented nationwide in Sierra Leone only. IPTi has been renamed as Perennial Malaria...
Arnaldo , Paulo;
Vallbona, Eduard Rovira;
Langa, Jerónimo S;
Salvador, Crizolgo;
Guetens, Pieter;
Chiheb, Driss;
Xavier , Bernardete;
Kestens, Luc;
Enosse, Sónia M;
Urgell , Anna Rosanas.
Malaria in pregnancy leads to serious adverse effects on the mother and the child and accounts for 75,000-200,000 infant deaths every year. Currently, the World Health Organization recommends intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) at each sche...
Pyrimethamine/administration & dosage,
Sulfadoxine/administration & dosage,
Antimalarials/therapeutic use,
d0082880,
d0149300,
d0149440,
d0090350,
Antimalarials/administration & dosage,
Pharmaceutical Preparations,
Health Facilities,
Drug Combinations,
Labor, Obstetric/radiation effects,
Pregnancy Complications, Parasitic,
Mozambique,
Risk Factors,
Malaria/prevention & control
Nhabomba, augusto J;
Guinovart, caterina;
Dobaño, carlota;
Alonso, pedro L;
Chitnis, chetan E;
Mayor, alfredo;
Aponte, john J;
Bassat, quique;
Rodríguez, mauricio H;
Barbosa, arnoldo;
Aguila, ruth;
Cisteró, pau;
Quintó, llorenç;
Manaca, maria N;
Jiménez, alfons.
Background: The impact of the age of first Plasmodium falciparum infection on the rate of acquisition of immunity to malaria and on the immune correlates of protection has proven difficult to elucidate. A randomized, double-blind, placebo-controlled trial using monthly chemoprophylaxis with sulphadoxine-...
Malaria, Falciparum/immunology,
Mozambique/epidemiology,
Pyrimethamine/therapeutic use,
Sulfadoxine/therapeutic use,
Adaptive Immunity,
Antigens, Protozoan/immunology,
Environmental Exposure,
Malaria, Falciparum/prevention & control,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/parasitology,
Enzyme-Linked Immunosorbent Assay,
Erythrocytes/parasitology,
Erythrocytes/immunology,
Chemoprevention
Hutton, guy;
Schellenberg, david;
Tediosi, fabrizio;
Macete, eusebio;
Kahigwa, elizeus;
Sigauque, betuel;
Mas, xavier;
Trapero, marta;
Tanner, marcel;
Menendez, clara;
Alonso, pedro;
Trilla, antoni.
Objective: To estimate the cost-effectiveness of malaria intermittent preventive treatment in infants (IPTi) using sulfadoxine-pyrimethamine (SP). Methods: In two previous IPTi trials in Ifakara (United Republic of Tanzania) and Manhiça (Mozambique), SP was administered three times to infants before 9 m...
Mayor, alfredo;
Casas, elisa serra;
Bardají, azucena;
Sanz, sergi;
Puyol, laura;
Cisteró, pau;
Sigauque, betuel;
Mandomando, inacio;
Aponte, john J;
Alonso, pedro L;
Menéndez, clara.
Background: Control of malaria in pregnancy remains a public health challenge. Improvements in its correct diagnosis and the adequacy of protocols to evaluate anti-malarial drug efficacy in pregnancy, are essential to achieve this goal.
Methods: The presence of Plasmodium falciparum was assessed by real-...
Malaria, Falciparum/epidemiology,
Merozoite Surface Protein 1,
Plasmodium falciparum,
Protozoan Proteins,
Pyrimethamine,
Malaria, Falciparum/therapy,
Malaria, Falciparum/parasitology,
Parasitemia/therapy,
Parasitemia/epidemiology,
Plasmodium falciparum/drug effects,
Plasmodium falciparum/genetics,
Plasmodium falciparum/isolation & purification,
Polymerase Chain Reaction,
Pregnancy Complications, Parasitic/therapy,
Pregnancy Complications, Parasitic/epidemiology,
Pregnancy Complications, Parasitic/parasitology
In late 2002, the health authorities of Mozambique implemented sulphadoxine-pyrimethamine (SP)/amodiaquine (AQ) as first-line treatment against uncomplicated falciparum malaria. In 2004, this has been altered to SP/artesunate in line with WHO recommendations of using Artemisinin Combination Therapies (AC...
Pyrimethamine/pharmacology,
Protozoan Proteins/genetics,
Malaria, Falciparum/epidemiology,
d0161330,
d0138120,
Mozambique/epidemiology,
Ligases,
Drug Combinations,
Drug Resistance/genetics,
Ezetimibe, Simvastatin Drug Combination/therapeutic use,
Pyrimethamine/supply & distribution,
Pharmaceutical Preparations,
Haplotypes/genetics,
Malaria, Falciparum/therapy,
Malaria, Falciparum/parasitology,
Plasmodium falciparum/radiation effects,
Plasmodium falciparum/isolation & purification,
Protozoan Proteins/standards,
Sulfadoxine/pharmacology
Menendez, clara;
Schellenberg, david;
Macete, eusebio;
Aide, pedro;
Kahigwa, elizeus;
Sanz, sergi;
Aponte, john J;
Sacarlal, jahit;
Mshinda, hassan;
Tanner, marcel;
Alonso, pedro L.
Background: Intermittent preventive treatment (IPTi) with sulphadoxine-pyrimethamine (SP) in infants resulted in different estimates of clinical malaria protection in two trials that used the same protocol in Ifakara, Tanzania, and Manhiça, Mozambique. Understanding the reasons for the discrepant result...
Schellenberg, david;
Kahigwa, elizeus;
Drakeley, chris;
Malende, athumani;
Wigayi, John;
Msokame, chris;
Aponte, john J;
Tanner, marcel;
Mshinda, hassan;
Menendez, clara;
Alonso, pedro L.
The safety and efficacy of amodiaquine (AQ), sulfadoxine-pyrimethamine (SP), and coadministered AQ+SP was assessed in 351 Tanzanian children (age range, 6-59 months) with uncomplicated Plasmodium falciparum malaria. This open, randomized study followed the 28-day World Health Organization (WHO) protocol ...
