A stratified random sample of 401 participants was taken from three sites of study (Maluti; Seboche and Paray) in rural Lesotho in an attempt to study the relationship between awareness about HIV/AIDS and 55 socio-economic and demographic variables. Pearson's chi-square tests of association and logistic regression analysis were used to identify factors that strongly affected awareness about HIV/AIDS. Results showed that awareness about HIV/AIDS was strongly affected by willingness to change sexual behaviour; regular use of condoms; sexually transmitted diseases; number of sexual partners and knowledge of transmission of the HIV/AIDS virus. Recommendations were made to promote health education in rural Lesotho on safe sex and the use of home-based care for people living with the virus