Raloxifene neutralizes bone brittleness induced by anti-remodeling treatment and increases fatigue life through non-cell mediated mechanisms
Actual. osteol; 12 (3), 2016
Pre-clinical data have shown that tissue level effects stemming from bisphosphonateinduced suppression of bone remodeling can result in bone that is stronger yet more brittle. Raloxifene has been shown to reduce bone brittleness through non-cellular mechanisms. The goal of this work was to test the hypot...
Ácido Zoledrónico/efectos adversos, Alendronato/efectos adversos, Clorhidrato de Raloxifeno/administración & dosificación, Clorhidrato de Raloxifeno/farmacología, Difosfonatos/efectos adversos, Fatiga/tratamiento farmacológico, Fenómenos Biomecánicos/efectos de los fármacos, Huesos/fisiopatología, Modelos Animales de Enfermedad, Osteogénesis Imperfecta/inducido químicamente, Osteogénesis Imperfecta/tratamiento farmacológico, Remodelación Ósea/efectos de los fármacos