β-ARRESTIN/CONNEXIN 43 (Cx43) complex anchors ERKS outside the nucleus: a prerequisite for bisphosphonate antiapoptotic effect mediated by Cx43/ERK in osteocytes
Actual. osteol; 12 (1), 2016
Bisphosphonates (BPs) anti-fracture efficacy may be due in part to inhibition of osteocyte
apoptosis. This effect requires opening of connexin (Cx) 43 hemichannels and phosphorylation of the extracellular signal regulated kinases (ERKs). However, unlike ERK activation by other stimuli, the Cx43/ERK pathw...
Apoptosis/efectos de los fármacos, beta-Arrestinas/metabolismo, Conexina 43/metabolismo, Difosfonatos/farmacología, Huesos/citología, Núcleo Celular/enzimología, Osteocitos/citología, Osteocitos/efectos de los fármacos, Osteocitos/metabolismo, Quinasas MAP Reguladas por Señal Extracelular/metabolismo, Supervivencia Celular/efectos de los fármacos