Alzheimer’s disease is the leading cause of dementia worldwide and a critical public health problem. While deaths from cardiovascular diseases have decreased, those attributed to Alzheimer’s disease have increased in recent years with no curative treatment to date. In this context, effective treatmen...
Colettis, Natalia;
Oberholzer, Maria;
Cercato, Magali;
Habif, Martin;
Selles, Maria;
Salas, Daniela;
Sebollela, Adriano;
Klein, William;
Epstein, Alberto;
Salvetti, Anna;
Ferreira, Sergio;
Jerusalinsky, Diana.
Strong evidence supports the hypothesis that synapse damage and memory impairment in early Alzheimer Disease (AD) might be due to synaptic failure caused by amyloid beta oligomers (AβOs). The preclinical efficacy of a single-chain variable fragment (scFv) antibody NUsc1 that ...
El objetivo del estudio fue investigar las funciones ejecutivas (fe) y los trastornos neuropsiquiátricos (tn) en pacientes con enfermedad de Alzheimer (ea), en función del grado de severidad, en comparación con sujetos sin deterioro cognitivo (ssdc). Se estudia-ron 50 pacientes c...
Background: Pternandra galeata belongs to the family Melastomataceae. It is a native flowering plant in Borneo Island that serve as food for monkey habitat. There has been limited study on the medicinal and chemical properties of this plant. Objectives: We investigated the acetylcholinesteras...
We present a 60-year-old woman with a 2-year history of progressive anterograde memory deficit, that evolved with a typical corticobasal syndrome with extrapyramidal signs and left superior limb dystonia. 18F-FDG and 11C-PIB PET/CT studies supported the diagnosis of Alzheimer’s disease associating a co...
La enfermedad de Alzheimer (EA) es la demencia más frecuente, considerada un proceso crónico e incurable. Los cuidadores de personas con EA pueden experimentar duelo anticipado. El objetivo fue observar el desarrollo de duelo anticipado en familiares de personas con EA. Participaron 10 cuidadore...
Introducción: la apolipoproteína E (APOE) es una glicoproteína implicada en el transporte de moléculas lipídicas. Se han descrito tres alelos del gen APOE: Ɛ2, Ɛ3 y Ɛ4. Varios estudios demuestran asociación de la isoforma APOE4 con Alzheimer de inicio tardío. Objetivos: determinar las fre...
Introducción: La enfermedad de Alzheimer (EA) se considera como una afección crónica con alta prevalencia a nivel mundial. Su sintomatología, el impacto que genera en el funcionamiento de la persona y los cambios que causa en su red de apoyo social, han llevado a que sea un tema de a...
The increase in life expectancy has led in recent years to neurodegenerative patholo-gies, such as Alzheimer’s disease, that were strange in the last century, now become so frequent that there is talk of a new epidemic. It is estimated that approximately 50 000 000 patients suffer dementia around th...
Alzheimer’s disease is, by far the first, cause of dementia and the more frequent neurodegenerative disease. Considered as a result of multifactorial causes, aging is the main risk factor for the classical form of the disease and because of global aging, a very significant increase in the prevalence is...
