INTRODUÇÃO: A organização de uma diretriz clínica é tarefa complexa, que necessariamente deve envolver planejamento prévio, coordenação apropriada, revisão aprofundada da literatura científica, com envolvimento de múltiplos profissionais da área da saúde com notório reconhecimento. A elabo...
OBJECTIVES: The authors aimed to determine the procedural learning curve and minimum annual institutional volumes associated with optimum clinical outcomes for transcatheter aortic valve replacement (TAVR).BACKGROUND: Transcatheter aortic valve replacement (TAVR) is a complex procedure requiring signific...
AIRE expression in thymus is downregulated by estrogen after puberty, what probably renders women more susceptible to autoimmune disorders. Here we investigated the efects of minipuberty on male and female infant human thymic tissue in order to verify if this initial transient increase in sex hormones - ...
OBJECTIVES: To explore the rate, the determinants of success, and the hemodynamic impact of balloon postdilatation (BPD) of self-expanding transcatheter heart valves (SE-THVs) Background: BPD is commonly used to optimize valve expansion and reduce paravalvular leakage (PVL) after transcatheter aortic val...
BACKGROUND: Left ventricular diastolic function is an important prognostic marker in acute coronary syndrome. However, classifcation of the dysfunction grade using isolated echocardiographic parameters remains difcult. Therefore, it is necessary to combine multiple data in diagnostic algorithms. The purp...