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Mitochondrial DNA haplogroups and variants predispose to chagas disease cardiomyopathy

Gallardo, Frédéric; Brochet , Pauline; Goudenège , David; Nunes, João Paulo Silva; Andrieux , Pauline; Ianni , Barbara Maria; Frade, Amanda Farage; Mady, Charles; Santos, Ronaldo Honorato Barros; Kuramoto , Andreia; Steffen, Samuel; Stolf, Antonio Noedir; Pomerantzeff , Pablo; Fiorelli, Alfredo Inacio; Bocchi, Edimar Alcides; Pissetti , Cristina Wide; Saba , Bruno; Dias, Fabrício C; Sampaio, Marcelo Ferraz; Gaiotto, Fabio Antônio; Marin-Neto , José Antonio; Fragata, Abílio; Zaniratto , Ricardo Costa Fernandes; Siqueira, Sergio; Peixoto , Giselle De Lima; Bacal, Fernando; Buck, Paula; Almeida, Rafael Ribeiro; Lin-Wang, Hui Tzu; Schmidt, André; Hirata, Mario Hiroyuki; Donadi, Eduardo Antonio; Pereira , Alexandre Costa; Junior , Virmondes Rodrigues; Martinelli, Martino; Naslavsky, Michel; Kalil, Jorge; Procaccio, Vincent; Cunha-Neto, Edecio; Chevillard , Christophe.
Hearts; 4 (4), 2023
Cardiomyopathies are major causes of heart failure. Chagas disease (CD) is caused by the parasite Trypanosoma cruzi, and it is endemic in Central and South America. Thirty percent of cases evolve into chronic chagas cardiomyopathy (CCC), which has worse prognosis as compared with other cardiomyopathies. ...
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