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Methylation status of LDLR, PCSK9 and LDLRAP1 is associated with cardiovascular events in familial hypercholesterolemia

Silva Rodrigues Marçal, Elisangela da; Borges, Jéssica Bassani; Bastos, Gisele Medeiros; Crespo Hirata, Thiago Dominguez; de Oliveira, Victor Fernandes; Gonçalves, Rodrigo Marques; Faludi, Andre Arpad; Dias França, João Italo; de Oliveira Silva, Daiana Vitor; Malaquias, Vanessa Barbosa; Luchessi, Andre Ducati; Silbiger, Vivian Nogueira; Nakazone, Marcelo Arruda; Carmo, Tayanne Silva; Silva Souza, Dorotéia Rossi; Crespo Hirata, Rosario Dominguez; Sampaio, Marcelo Ferraz; Hirata, Mario Hiroyuki.
Epigenomics (Online); 16 (11-12), 2024
AIM: Methylation of LDLR, PCSK9 and LDLRAP1 CpG sites was assessed in patients with familial hypercholesterolemia (FH). METHODS: DNA methylation of was analyzed by pyrosequencing in 131 FH patients and 23 normolipidemic (NL) subjects. RESULTS: LDLR, PCSK9 and LDLRP1 methylation was similar between FH pat...
^dd0191750, ^dd0069380, ^dd0154150, ^dd0590140
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