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Atorvastatin therapy for prevention of anthracycline-induced cardiotoxicity in cancer patients: a meta-analysis

Bulhoes, Elisio; Farias, Carlos; Florindo, Mayara; Silva, Gustavo Fernandes da; Holmvard, Oscar; Silva, Ana Laura Soares; Ferreira, Andre Carvalho; Sales, Gabriel; Schneider, Andre; Roesch, Heveline Rayane Moura; Guida, M Camila.
Circulation; 150 (Suppl. 1), 2024
INTRODUCTION: Cancer therapy-induced cardiac dysfunction is a significant adverse effect of chemotherapeutic agents, particularly anthracyclines (ANT). High-potency statin therapy, such as atorvastatin, appears to exert a protective effect against this condition. OBJECTIVE: We aimed to perform a meta-ana...
Atorvastatina, Cardiotoxicidade, Inibidores de Hidroximetilglutaril-CoA Redutases, Insuficiência Cardíaca, Interpretação Estatística de Dados, Neoplasias da Mama
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Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervention on Major Adverse Cardiovascular Events in Acute Coronary Syndrome The SECURE-PCI Randomized Clinical Trial

Berwanger, Otavio; Santucci, Eliana Vieira; Silva, Pedro Gabriel Melo de Barros e; Jesuíno, Isabella de Andrade; Damiani, Lucas Petri; Barbosa, Lilian Mazza; Santos, Renato Hideo Nakagawa; Laranjeira, Ligia Nasi; Egydio, Flávia de Mattos; Oliveira, Juliana Aparecida Borges de; Dall Orto, Frederico Toledo Campo; Andrade, Pedro Beraldo de; Bienert, Igor Ribeiro de Castro; Bosso, Carlos Eduardo; Mangione, José Armando; Polanczyk, Carisi Anne; Sousa, Amanda Guerra de Moraes Rego; Kalil, Renato Abdala Karam; Santos, Luciano de Moura; Sposito, Andrei Carvalho; Rech, Rafael Luiz; Sousa, Antônio Carlos Sobral; Baldissera, Felipe; Nascimento, Bruno Ramos; Giraldez, Roberto Rocha Corrêa Veiga; Cavalcanti, Alexandre Biasi; Pereira, Sabrina Bernardez; Mattos, Luiz Alberto; Armaganijan, Luciana Vidal; Guimarães, Hélio Penna; Sousa, José Eduardo Moraes Rego; Alexander, John Hunter; Granger, Christopher Bull; Lopes, Renato Delascio.
JAMA; 319 (13), 2018
IMPORTANCE The effects of loading doses of statins on clinical outcomes in patients with acute coronary syndrome (ACS) and planned invasive management remain uncertain. OBJECTIVE To determine if periprocedural loading doses of atorvastatin decrease 30-day major adverse cardiovascular events (MACE) in pat...
Atorvastatina, Síndrome Coronariana Aguda, Angiografia Coronária