Cardiolipin-metabolite crosstalk in HFpEF
Circ. res; 135 (Suppl. 1), 2024
BACKGROUND: Transition from fatty acid oxidation to glycolysis is linked to oncometabolism and cardiac hypertrophy. We hypothesize that such a metabolic shift is pivotal in driving HFpEF in 3 murine models. The citric acid cycle (CAC) enzyme αKGDH is dysregulated in HFpEF patient biopsies and Alport hea...