Resultados: 15

Colesterol não controlado em indivíduos com hipercolesterolemia grave acompanhados em um programa de avaliação da saúde no Brasil
Uncontrolled Cholesterol in Individuals with Severe Hypercholesterolemia in a Health Evaluation Program in Brazil

Arq. bras. cardiol; 121 (11), 2024
FUNDAMENTO Indivíduos com hipercolesterolemia grave (HG) são considerados sob alto risco de desenvolverem aterosclerose e devem ser intensivamente tratados com medicamentos hipolipemiantes, visando uma redução nos níveis de LDL-Colesterol ≥50% e uma meta <70 mg/dL. OBJETIVOS Este estudo teve como ...

Key performance indicators of secondary health care in chronic kidney disease: experience in public and private Services in the state of São Paulo, Brazil

Int J Nephrol; (), 2024
INTRODUCTION: The objective of this study was to evaluate quality indicators of secondary health care in chronic kidney disease (CKD). METHODS: This retrospective longitudinal study was conducted in an outpatient medical nephrology clinic of the Brazilian Unified Health System (UHS) and a multidisciplina...

HIV and cardiovascular risk: should we use other targets for cholesterol control? Brazilian data compared to major studies

Eur. heart j; 45 (Suppl. 1), 2024
In daily clinical practice, cardiologists are confronted with patients with HIV/AIDS and this population needs special attention due to their higher cardiovascular risk. Studies show an increase in cardiovascular disease (CVD) among people with HIV/AIDS and one of the main causes of death in this group. ...

Identification of apob variants in samples from the brazilian population with hypercholesterolemic phenotype

Arq. bras. cardiol; 120 (9 supl. 1), 2023
INTRODUCTION AND OBJECTIVES: Apolipoprotein B plays a crucial role in regulating plasma cholesterol by mediating the interaction of low-density lipoprotein (LDL) with LDL receptors in the liver. Inherited mutations in this gene may increase the risk of developing premature atherosclerotic cardiovascular ...

Primary prevention of cardiovascular disease at community clinics in the state of Sao Paulo, Brazil: results from the epidemiological information study of communities

Glob. heart (Online); 18 (1), 2023
BACKGROUND: Primary prevention of cardiovascular disease (CVD) remains a major challenge, especially in communities of low- and middle-income countries with poor medical assistance influenced by distinct local, financial, infrastructural, and resource-related factors. OBJECTIVE: This a community-based st...

Avaliação do conhecimento de médicos especialistas sobre a hipercolesterolemia familiar
Assessment of the knowledge of specialist physicians about familial hypercholesterolemia

Arq. bras. cardiol; 117 (4 supl. 2), 2021
INTRODUÇÃO: A hipercolesterolemia familiar (HF) é uma doença hereditária autossômica codominante marcada por altos níveis de colesterol ligado à lipoproteína de baixa densidade (LDL-c), associando-se a um risco de 10 a 13 vezes maior de desenvolvimento de doença cardiovascular aterosclerótica....

Variante no gene LDL-R associada com elevação do LDL-C identificada em um portador de hipercolesterolemia familiar
LDL-R gene variant associated with LDL-C elevation identified in a carrier of familial hypercholesterolemia

Arq. bras. cardiol; 117 (4 supl. 2), 2021
INTRODUÇÃO: A hipercolesterolemia familiar (HF) é uma doença hereditária autossômica codominante marcada por altos níveis de colesterol ligado à lipoproteína de baixa densidade (LDL-c). Pode-se apresentar na forma homozigótica, apresentando prevalência de 1/160.000 a 1/1.000.000 ou na forma he...

Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: results of 8. 7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants

Eur. heart j; 42 (31), 2021
AIMS Rosuvastatin (10 mg per day) compared with placebo reduced major adverse cardiovascular (CV) events by 24% in 12 705 participants at intermediate CV risk after 5.6 years. There was no benefit of blood pressure (BP) lowering treatment in the overall group, but a reduction in events in the third of pa...

Reductive power generated by Mycobacterium leprae through cholesterol oxidation contributes to lipid and ATP synthesis

Upon infection, Mycobacterium leprae, an obligate intracellular bacillus, induces accumulation of cholesterol-enriched lipid droplets (LDs) in Schwann cells (SCs). LDs are promptly recruited to M. leprae-containing phagosomes, and inhibition of this process decreases bacterial survival, suggesting that L...

Perfil bioquímico de pacientes diabéticos de um laboratório privado da região sul do Brasil

O diabetes é uma doença crônica decorrente de hiperglicemia permanente. A hemoglobina glicada (HbA1c) resulta da ligação não enzimática entre a hemoglobina e a glicose. A dosagem da mesma é o principal determinante para avaliação do controle glicêmico em pacientes diabéticos. Este estudo obj...