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Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy

Brochet, Pauline; Ianni, Barbara Maria; Laugier, Laurie; Frade, Amanda Farage; Nunes, João Paulo Silva; Teixeira, Priscila Camillo; Mady, Charles; Ferreira, Ludmila Rodrigues Pinto; Ferré, Quentin; Santos, Ronaldo Honorato Barros; Kuramoto, Andreia; Cabantous, Sandrine; Steffen, Samuel; Stolf, Antonio Noedir; Pomerantzeff, Pablo; Fiorelli, Alfredo Inacio; Bocchi, Edimar Alcides; Pissetti, Cristina Wide; Saba, Bruno; Cândido, Darlan da Silva; Dias, Fabrício C; Sampaio, Marcelo Ferraz; Gaiotto, Fabio Antônio; Marin-Neto, José Antonio; Fragata, Abílio; Zaniratto, Ricardo Costa Fernandes; Siqueira, Sergio; Peixoto, Giselle De Lima; Rigaud, Vagner Oliveira-Carvalho; Bacal, Fernando; Buck, Paula; Almeida, Rafael Ribeiro; Lin-Wang, Hui Tzu; Schmidt, André; Martinelli, Martino; Hirata, Mario Hiroyuki; Donadi, Eduardo Antonio; Pereira, Alexandre Costa; Rodrigues Junior, Virmondes; Puthier, Denis; Kalil, Jorge; Spinelli, Lionel; Cunha-Neto, Edecio; Chevillard, Christophe.
Front. immunol; 13 (958200), 2022
Abstract: Chagas disease, caused by the protozoan Trypanosoma cruzi, is an endemic parasitic disease of Latin America, affecting 7 million people. Although most patients are asymptomatic, 30% develop complications, including the often-fatal Chronic Chagasic Cardiomyopathy (CCC). Although previous studies...
Cardiomiopatia Chagásica, Doença de Chagas/genética, Epigênese Genética, Fatores de Transcrição/genética, Trypanosoma cruzi, Metilação
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