Freitas, Renata Caroline Costa de;
Bortolin, Raul Hernandes;
Kuraoka, Shiori;
Rogers, Maximillian A;
Blaser, Mark C;
Chelvanambi, Sarvesh;
Borges, Jessica Bassani;
Oliveira, Victor Fernandes de;
Dagli-Hernandez, Carolina;
Bastos, Gisele Medeiros;
Marçal, Elisangela da Silva Rodrigues;
Malaquias, Vanessa Barbosa;
Gonçalves, Rodrigo Marques;
Faludi, Andre Arpad;
Silbiger, Vivian Nogueira;
Luchessi, André Ducati;
Aikawa, Masanori;
Hirata, Rosario Dominguez Crespo;
Singh, Sasha A;
Aikawa, Elena;
Hirata, Mario Hiroyuki.
BACKGROUND AND AIMS: Familial Hypercholesterolemia (FH) is a monogenic disease that leads to early-onset atherosclerosis. Causative mutations in FH-related genes are found in 60-80 % of patients, while epigenetic factors may contribute to mutation-negative cases. This study analyzed miRNAs and proteins f...
Pivatto Júnior, Fernando;
Santos, Ângela Barreto Santiago;
Englert, Eduarda Foresti;
Mazzutti, Géris;
Costa, Guilherme Oliveira Magalhães;
Saffi, Marco Aurélio Lumertz;
Siebert, Marina;
Liedke, Pedro Emanuel Rubini;
Fritsch, Vinícius Henrique;
Biolo, Andreia.
BACKGROUND: The classic biomarkers troponin and brain natriuretic peptide (BNP), as well as the currently available risk scores, are far from being considered ideal for predicting cancer therapy-related cardiac dysfunction (CTRCD). MicroRNAs (miRNAs) are promising biomarkers for better identification of ...
BACKGROUND: Chagas cardiomyopathy (ChCM) is a severe form of Chagas disease and a major cause of cardiovascular morbidity and mortality. The dysregulation of the immune response leads to cardiac remodeling and functional disruptions, resulting in life-threatening complications. Conventional diagnostic me...
A toxoplasmose é uma zoonose cosmopolita e quando a infecção ocorre durante a gravidez (toxoplasmose gestacional) o parasita pode atravessar a placenta, causando a forma congênita, e causar danos graves. Investigar como os microRNAs regulam a infecção pode oferecer informações valiosas sobre sua ...
de Freitas, Renata Caroline Costa;
Bortolin, Raul Hernandes;
Borges, Jessica Bassani;
de Oliveira, Victor Fernandes;
Dagli-Hernandez, Carolina;
Marçal, Elisangela da Silva Rodrigues;
Bastos, Gisele Medeiros;
Gonçalves, Rodrigo Marques;
Faludi, Andre Arpad;
Silbiger, Vivian Nogueira;
Luchessi, André Ducati;
Hirata, Rosario Dominguez Crespo;
Hirata, Mario Hiroyuki.
BACKGROUND
Familial hypercholesterolemia (FH) is caused by pathogenic variants in low-density lipoprotein (LDL) receptor (LDLR) or its associated genes, including apolipoprotein B (APOB), proprotein convertase subtilisin/kexin type 9 (PCSK9), and LDLR adaptor protein 1 (LDLRAP1). However, approximately 4...
As vesículas extracelulares (EVs) são nanopartículas produzidas e liberadas por células eucarióticas e procarióticas com propriedades biológicas. EVs desempenham um papel importante no sistema imunológico, transporte de moléculas e comunicação celular. A fim de compreender a participação das...
Quintanilha, Julia C. F;
Cursino, Maria A;
Borges, Jessica B;
Torso, Nadine G;
Bastos, Larissa B;
Oliveira, Juliana M;
Cobaxo, Thiago S;
Pincinato, Eder C;
Hirata, Mario H;
Geraldo, Murilo V;
Lima, Carmen S. P;
Moriel, Patricia.
BACKGROUND: No biomarker is available for identifying cancer patients at risk of developing nephrotoxicity when treated with cisplatin. METHODS: We performed microRNA (miRNA) sequencing using plasma collected 5 days after cisplatin treatment (D5) from twelve patients with head and neck cancer with and wi...
Los, Bruna;
Borges, Jéssica B;
Oliveira, Victor F;
Freitas, Renata C. C;
Dagli-Hernandez, Carolina;
Bortolin, Raul H;
Gonçalves, Rodrigo M;
Faludi, André A;
Rodrigues, Alice C;
Bastos, Gisele M;
Jannes, Cinthia E;
Pereira, Alexandre C;
Hirata, Rosario D. C;
Hirata, Mario H.
AIM: functional analysis of pcsk9 3'utr variants and mrna-mirna interactions were explored in patients with familial hypercholesterolemia (fh). MATERIALS & METHODS: PCSK9 3'UTR variants were identified by exon-targeted gene sequencing. Functional effects of 3'UTR variants and mRNA-miRNA interactions were...
Braga, Aécio A;
Bortolin, Raul H;
Graciano-Saldarriaga, Magda E;
Hirata, Thiago Dc;
Cerda, Alvaro;
Freitas, Renata Cc de;
Lin-Wang, Hui T;
Borges, Jessica B;
França, João Id;
Masi, Laureane N;
Curi, Rui;
Pithon-Curi, Tania C;
Sampaio, Marcelo F;
Castro, Lara R;
Bastos, Gisele M;
Hirata, Rosario Dc;
Hirata, Mario H.
ABSTRACT: To explore the association of circulating miRNAs with adiposity, metabolic status and inflammatory biomarkers in patients with metabolic syndrome (MetS). METHODS: Serum levels of 372 miRNAs were measured in patients with (n = 6) and without MetS (n = 6) by quantitative PCR array, and dysregulat...
