Myelination key factor krox‐20 is downregulated in Schwann cells and murine sciatic nerves infected by Mycobacterium leprae
Schwann cells (SCs) critically maintain the plasticity of the peripheral nervous system. Peripheral nerve injuries and infections stimulate SCs in order to retrieve homeostasis in neural tissues. Previous studies indicate that Mycobacterium leprae (ML) regulates the expression of key factors related to S...
Hanseníase/metabolismo, Células de Schwann/microbiologia, Hanseníase/microbiologia, Mycobacterium leprae/isolamento & purificação, Nervos Periféricos/microbiologia, Regulação para Baixo, Plasticidade Neuronal/fisiologia, Técnicas In Vitro, Receptores de Fator de Crescimento Neural/fisiologia, Células de Schwann/metabolismo, Proteína 2 de Resposta de Crescimento Precoce/biossíntese