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Aficamten vs metoprolol for obstructive hypertrophic cardiomyopathy: MAPLE-HCM rationale, study design, and baseline characteristics

Garcia-Pavia, Pablo; Bilen, Ozlem; Burroughs, Melissa; Costabel, Juan Pablo; de Barros Correia, Edileide; Dybro, Anne M; Elliott, Perry; Lakdawala, Neal K; Mann, Amy; Nair, Ajith; Nassif, Michael E; Poulsen, Steen H; Reant, Patricia; Schulze, P Christian; Wang, Andrew; Berhane, Indrias; Heitner, Stephen B; Jacoby, Daniel L; Kupfer, Stuart; Malik, Fady I; Meng, Lisa; Sohn, Regina; Wohltman, Amy; Fifer, Michael A.
JACC. Heart failure (Online); 13 (2), 2025
Beta-blockers and nondihydropyridine calcium-channel blockers have been standard-of-care (SOC) medications for patients with symptomatic obstructive hypertrophic cardiomyopathy (oHCM), even though these agents do not directly affect the underlying pathophysiology of the disease. Cardiac myosin inhibitors...
Metoprolol/uso terapêutico, Cardiomiopatia Hipertrófica/tratamento farmacológico, Antagonistas de Receptores Adrenérgicos beta 1/uso terapêutico, Uracila/análogos & derivados, Resultado do Tratamento, Tolerância ao Exercício/efeitos dos fármacos, Obstrução da Via de Saída Ventricular Direita/tratamento farmacológico
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Ischemia severity, coronary artery disease extent, and exercise capacity in ischemia

Fleg, Jerome L; Huang, Zhen; Reynolds, Harmony R; Shaw, Leslee J; Chaitman, Bernard R; O'Brien, Sean M; Berstein, Leonid; Peteiro, Jesus; Smanio, Paola EP; Wander, Gurpreet S; Berger, Jeffrey S; Berman, Daniel S; Picard, Michael H; Kwong, Raymond Y; Min, James K; Phillips, Lawrence M; Bangalore, Sripal; Maron, David J; Hochman, Judith S.
Circulation; 150 (2), 2024
Doença da Artéria Coronariana/diagnóstico, Tolerância ao Exercício, Isquemia Miocárdica/fisiopatologia, Índice de Gravidade de Doença, Teste de Esforço, Isquemia
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Home-based training program in patients with chronic heart failure and reduced ejection fraction: a randomized pilot study

Andrade, Geisa Nascimento de; Umeda, Iracema Ioco Kikuchi; Fuchs, Angela Rubia Cavalcanti Neves; Mastrocola, Luiz Eduardo; Rossi-Neto, João Manoel; Moreira, Dalmo Antonio Ribeiro; Oliveira, Patricia Alves de; André, Carmen Diva Saldiva de; Cahalin, Lawrence Patrick; Nakagawa, Naomi Kondo.
Clinics; 76 (), 2021
OBJECTIVES: We aimed to compare the effects of home-and center-based exercise training programs on functional capacity, inspiratory muscle strength, daily physical activity level, and quality of life (QoL) in patients with chronic heart failure (CHF) over a 12-week period. METHODS: This study included 2...
Terapia por Exercício, Tolerância ao Exercício, Força da Mão, Insuficiência Cardíaca/terapia, Projetos Piloto, Qualidade de Vida, Volume Sistólico, Função Ventricular Esquerda
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