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Predicted deleterious variants in ABCA1, LPL, LPA and KIF6 are associated with statin response and adverse events in patients with familial hypercholesterolemia and disturb protein structure and stability

Dagli-Hernandez, Carolina; Ferreira, Glaucio Monteiro; Freitas, Renata Caroline Costa de; Borges, Jessica Bassani; Oliveira, Victor Fernandes de; Gonçalves, Rodrigo Marques; Faludi, Andre Arpad; Marçal, Elisangela da Silva Rodrigues; Bastos, Gisele Medeiros; Bortolin, Raul Hernandes; Hirata, Mario Hiroyuki; Hirata, Rosario Dominguez Crespo.
Pharmacogenet. genomics; 34 (4), 2024
OBJECTIVES: This study explored the association of deleterious variants in pharmacodynamics (PD) genes with statin response and adverse effects in patients with familial hypercholesterolemia (FH) and analyzed their potential effects on protein structure and stability. METHODS: Clinical and laboratory dat...
Inibidores de Hidroximetilglutaril-CoA Redutases, Hiperlipoproteinemia Tipo II, Transportador 1 de Cassete de Ligação de ATP, Lipase Lipoproteica
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