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Comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: a pilot study

Borges, Luiz Gustavo dos Anjos; Giongo, Adriana; Pereira, Leandro de Mattos; Trindade, Fernanda J; Gregianini, Tatiana Schaffer; Campos, Fabrício Souza; Ghedin, Elodie; Veiga, Ana Beatriz Gorini da.
Health Sci Rep; 1 (6), 2018
Aims: Influenza A virus (IAV) can cause severe acute respiratory infection (SARI), and disease outcome may be associated with changes in the microbiome of the nasopharynx. This is a pilot study to characterize the microbiome of the nasopharynx in patients hospitalized with SARI, infected and not infected...
Vírus da Influenza A, Coinfecção, Nasofaringe, Projetos Piloto, Infecções Respiratórias, Microbiota, Doenças Respiratórias, Pseudomonas, Streptococcus, RNA Ribossômico 16S
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Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance

Souza, Thiago Moreno Lopes e; Fintelman-Rodrigues, Natalia; Resende, Paola Cristina; Mesquita, Milene; Gregianini, Tatiana Schaffer; Bozza, Fernando A; Pecego, Ana Carla; Fernandes, Sandra Bianchini; Cury, Ana Luisa Furtado; Riediger, Irina Nastassja; Siqueira, Marilda M.
Mem. Inst. Oswaldo Cruz; 110 (1), 2015
The 2009 pandemic influenza A virus outbreak led to the systematic use of the neuraminidase (NA) inhibitor oseltamivir (OST). Consequently, OST-resistant strains, carrying the mutation H275Y, emerged in the years after the pandemics, with a prevalence of 1-2%. Currently, OST-resistant strains have been f...
Mutação/efeitos dos fármacos, Farmacorresistência Viral, Vírus da Influenza A, Oseltamivir/farmacologia
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