BACKGROUND Since its commercialization in 2007, the number of transcatheter aortic valve replacement (TAVR) procedures has grown exponentially worldwide. The penetrance of TAVR in Latin America compared to North America and Europe, remains unknown. We sought to examine the penetrance of TAVR in Latin America compared to Europe and North America. METHODS Data were collected from the BIBA MedTech registry obtained by continuous surveillance by lead physicians performing TAVR procedures in North America, Europe, and Latin America. An online form describing the number of TAVR procedures, type of device (selfexpandable [SE] and balloon-expandable [BE]), and access routes was used. Variation between regions was assessed using the incidence rate ratio with Poisson analysis. Significance was assumed at p< 0.05). RESULTS Between 2014 and 2023, the number of TAVR was higher in North America (613.790 procedures) and Europe (618.161 procedures) compared to Latin America (30.874 procedures). Over the 9-year study period, North America experienced a substantial increment in TAVR procedures (15.190 vs. 98.285), as did Europe (26.743 vs. 98.647 TAVR), while Latin America showed a modest increment (1.088 vs. 6.566 TAVR) (Figure 1). The most used device in North America was BE (71%), while SE was more frequently used in Europe and Latin America (52% and 65%, respectively). Overall, the transfemoral approach was the most utilized (92%), followed by the subclavian route (2.2%). The rate of TAVR per 100,000 population in 2023, was significantly lower in Latin America compared to North America (1.51 vs 17.57, IRR 0.08 CI95 [0.009 - 0.35], p < 0.001) and Europe (1.51 vs 21.39, IRR 0.09 CI95% [0.01 - 0.38], p<0.001). CONCLUSION TAVR adoption in Latin America has been slow, significantly trailing behind the rates observed in North America and Europe.