Objective: Pax-7 and Myo-D regulate satellite cells’ activation and differentiation, thus muscle regeneration following damage. This research aimed to investigate the effect of Thymoquinone (TQ) on skeletal muscle regeneration following 7,12-dimethylbenz-(a)-anthracene (DMBA...
Squamous cell carcinoma (SCC) is a non-melanoma skin cancer, with chronic sun exposure as the main risk factor. Excisional surgery is the most indicated treatment; however, patients can suffer functional, aesthetic, and psychological damage depending on the lesion site. Topical administration of 7,12-dim...
Introduction: DMBA is a chemical carcinogen that induces carcinomas within a few weeks of its application. We developed an experimental model of carcinogenesis induced by DMBA dissolved in 0,5% paraffin oil (DMBA-PO), verifying the inhibitory effect of the carcinogenicity of phenyl isothiocyanate (PhITC)...
Abstract Aims: To identify the histopathological alterations in organs of Wistar rats to evaluate toxic effects of use of Annonamuricata Raw Leaf Extract (AMRLE) alone or in association with DMBA. Settings and Design: Sixty female Wistar rats were used, separated into groups and treated with a single dos...
Objective: κ-carrageenan is a food stabilizer agent which has an antiproliferative effect, while vitamin D is a prohormone acts on the nuclear receptor and has a cytotoxic against cancer. This study aimed to show the synergistic effect of using topical κ-carrageenan and oral administration of the vitam...
Abstract Purpose: To examine the effects of Arrabidaa chica (Bignoniacea) extract, a native plant of the Amazon known as crajiru, on a 7,12-dimethyl-1,2-benzanthracene (DMBA)-induced breast cancer model in Wistar rats. Methods: We compared the response of breast cancer to the oral administration of A. ...
9,10-Dimetil-1,2-benzantraceno,
Antineoplásicos/farmacología,
Antineoplásicos/uso terapéutico,
Bignoniaceae/química,
Neoplasias de la Mama/diagnóstico por imagen,
Neoplasias de la Mama/tratamiento farmacológico,
Neoplasias de la Mama/patología,
Carcinógenos,
Carcinoma/diagnóstico por imagen,
Carcinoma/tratamiento farmacológico,
Carcinoma/patología,
Catalasa/análisis,
Fluorodesoxiglucosa F18,
Glutatión Peroxidasa/análisis,
Neoplasias Experimentales/tratamiento farmacológico,
Extractos Vegetales/farmacología,
Ratas Wistar,
Vincristina/farmacología,
Resultado del Tratamiento
The aim of this study was to assess the effect of oral administration of Hydroalcoholic Extract of Green Propolis (HEGP) on dermal carcinogenesis in rodent model. For the biological assay, we used 36 mice, assigned into 6 groups (n=6): CTR (treated with 100 mg/kg HEGP and no tumor induction), TUM (treate...
Própolis/administración & dosificación,
Própolis/farmacología,
Neoplasias Cutáneas/prevención & control,
Administración Oral,
Carcinogénesis/efectos de los fármacos,
Alcoholes,
Própolis/química,
Flavonoides/análisis,
Quimioprevención,
Neoplasias Cutáneas/inducido químicamente,
9,10-Dimetil-1,2-benzantraceno,
Modelos Animales de Enfermedad
Estudou-se de forma comparativa, os efeitos de peróxido de hidrogênio sobre a mucosa bucal de hamsters. Utilizou-se 96 animais, divididos em 8 grupos, aplicando-se: água destilada; DMBA; peróxido de carbamida a 10 por cento com carbopol; peróxido de hidrogênio a 27 por cento; dentifrício com peró...
Com o objetivo de observar o comportamento biológico, macro e microscópico, da mucosa lingual lateral de hamsters sírios dourados Mesocricetus auratus após contato direto com bebidas de alto teor alcoólico (cachaça e uísque) associadas ao 9,10 dimetil1,2-benzantraceno (DMBA) realizou-se este traba...
Com o objetivo de observar o comportamento biológico, macro e microscópio, da mucosa lingual lateral de hamsters sírios dourados Mesocricetus auratus após contato direto com bebidas alcoólicas de alto teor (cachaça e uísque) e de uma revisäo literária sobre o relacionamento álcool/câncer bucal...
