SUMMARY: To investigate if the administration of boric acid (BA) would exert any protective effect against possible nephrotoxicity and hepatotoxicity induced by the exposure to acrylamide (ACR) in rats. In our study, we used a total of 28 rats that were divided into four equal groups. Group 1: the contro...
Ácidos Bóricos/administración & dosificación,
Lesión Renal Aguda/prevención & control,
Lesión Renal Aguda/inducido químicamente,
Enfermedad Hepática Inducida por Sustancias y Drogas/prevención & control,
Acrilamida/toxicidad,
Sustancias Protectoras/administración & dosificación,
Hígado/efectos de los fármacos,
Riñón/efectos de los fármacos,
Lesión Renal Aguda/patología,
Enfermedad Hepática Inducida por Sustancias y Drogas/patología,
Bioquímica,
Riñón/fisiopatología,
Hígado/fisiopatología
SUMMARY: Acrylamide (AA) is a widely used chemical and an important monomer in various industrial and laboratory processes. In addition, AA is formed during processing of starchy food at high temperature. The aim of our study was to examine effects of subchronic AA treatment on adult rat liver using hist...
RESUMEN En abril de 2002, un grupo de investigadores suecos dio a conocer que algunos alimentos ricos en almidón y pobres en proteínas, sometidos a procesos con temperaturas mayores a 120 °C (fritura, horneado, asado y tostado) contenían el procancerígeno conocido como acrilamida, un "probable carci...
ABSTRACT Objective Acrylamide is a toxic compound widely used in industrial sectors. Acrylamide causes reactive oxygen species formation and the subsequent lipid peroxidation reaction, which plays an important role in the pathogenesis of oxidative damage. Taxifolin is a flavonoid with antioxidant proper...
Abstract Acrylamide is a neurotoxic compound. Moreover, anakinra is an interleukin-1 (IL-1) receptor antagonist used in rheumatoid arthritis treatment. This study investigated the effect of anakinra on acrylamide-related neuropathy and neuropathic pain. Acrylamide exposure caused a significant decrease ...
SUMMARY: Acrylamide is a toxic chemical substance with wide implementation in chemical industry. In 2002 the presence of acrylamide was discovered in foods rich in starch which are prepared at high temperatures. The aim of this study was to investigate the histopathological changes in the gastric tissue ...
The enzyme L-asparaginase (ASNase) is broadly applied as a drug to treat acute lymphoblastic leukemia, as well as in the food industry to avoid acrylamide formation in baked and fried food. In the present work, ASNase was covalently attached to polyethylene glycol (PEG) of different molecular weights (AS...
SUMMARY: Acrylamide (ACR) is a cytotoxic and carcinogenic material. It is a product of a Maillard reaction during the cooking of many types of fried fast food, e.g. potato chip fries, and chicken nuggets. ACR has a severe toxic effect on different body organs. This study investigates the hepatotoxic effe...
Ácido Ascórbico/farmacología,
Silimarina/farmacología,
Acrilamida/toxicidad,
Hígado/efectos de los fármacos,
Hígado/metabolismo,
Hígado/patología,
Antígenos CD/análisis,
Actinas/análisis,
Inmunohistoquímica,
Células Estrelladas Hepáticas,
Hepatocitos
ABSTRACT Objective Acrylamide is a potentially neurotoxic and carcinogenic chemical and naturally creates during the heating process of carbohydrate-rich foods, such as potato chips and breakfast cereals. Acrylamide might be ingested by people via consuming food that contains it. Therefore, we investiga...
SUMMARY: Biomaterials are mostly polymers and are used in artificial organ production in contemporary medicine. They are prepared by the polymerization reaction of many monomers. There are many monomers used in biomaterial production. In this study, we investigated whether acrylamide (AAm), methacrylamid...
