INTRODUCTION: The resistance of fungal species to drugs usually used in clinics is of great interest in the medical field. OBJECTIVE: To evaluate susceptibility and in vitro response of species of Trichophyton spp. to antifungal drugs of interest in clinical medicine. METHODS: 12 samples of clinical isol...
Tiña/tratamiento farmacológico,
Susceptibilidad a Enfermedades/microbiología,
Trichophyton/efectos de los fármacos,
Antifúngicos/farmacología,
Recuento de Colonia Microbiana,
Farmacorresistencia Fúngica,
Tiña/microbiología,
Pruebas de Sensibilidad Microbiana,
Anfotericina B/farmacología,
Cetoconazol/farmacología,
Itraconazol/farmacología,
Fluconazol/farmacología
Silva, Tássio Henrique Sousa;
Araújo, Claudiane Vansoski;
Santos, Khelvin Myner da Costa;
Alves, Nathanael dos Santos;
Gomes, Thayse Haylene Soares;
Silva, Andressa Kelly Ferreira e;
Silva, Nayra Cristina Lira dos Santos;
Damasceno Júnior, Evandro César Bezerra;
Carvalho, Andressa Maria Aguiar de;
Mendes, Maria Gabriela Araújo;
Caminha, Henrique Barros;
Daboit, Tatiane Caroline;
Ferreira, Thatiana Bragine;
Andrade-Silva, Leonardo Eurípedes;
Silva-Vergara, Mario León;
Ferreira-Paim, Kennio;
Fonseca, Fernanda Machado.
BACKGROUND: Statins are used as cholesterol-lowering drugs and may also have direct antimicrobial effects. OBJECTIVE: To evaluate synergic interactions between simvastatin and both amphotericin B and fluconazole, against environmental strains of Cryptococcus neoformans isolated from captive birds' dro...
Abstract Introduction Otomycosis is a common problem in otolaryngology practice. However, we usually encounter some difficulties in its treatment because many patients show resistance to antifungal agents, and present high recurrence rate. Objectives To determine the fungal pathogens that cause otomyco...
Otomicosis/microbiología,
Antifúngicos/farmacología,
Farmacorresistencia Fúngica,
Hongos/aislamiento & purificación,
Aspergillus/aislamiento & purificación,
Candida/aislamiento & purificación,
Voriconazol/farmacología,
Anfotericina B/farmacología,
Terbinafina/farmacología,
Itraconazol/farmacología,
Epidemiología Descriptiva,
Pruebas de Sensibilidad Microbiana,
Levaduras/aislamiento & purificación,
28573,
Aspergillus niger/aislamiento & purificación
Abstract Amphotericin B is a fungicidal substance that is treatment of choice for most systemic fungal infections affecting immunocompromised patients. However, severe side effects have limited the utility of this drug. The aim of this study was to evaluate the antifungal effect of the combination of amp...
Abstract INTRODUCTION We describe the clinical and laboratorial features of oral candidiasis in 66 HIV-positive patients. METHODS: Polymerase chain reaction-based techniques were performed for differentiation of Candida spp. isolated from patients at a public teaching hospital in Midwest Brazil. RESU...
Infecciones Oportunistas Relacionadas con el SIDA/diagnóstico,
Infecciones Oportunistas Relacionadas con el SIDA/microbiología,
Anfotericina B/farmacología,
Antifúngicos/farmacología,
Brasil,
Candida/clasificación,
Candida/efectos de los fármacos,
Candida/aislamiento & purificación,
Candidiasis Bucal/diagnóstico,
Candidiasis Bucal/microbiología,
Farmacorresistencia Microbiana,
Fluconazol/farmacología,
Itraconazol/farmacología,
Pruebas de Sensibilidad Microbiana,
Persona de Mediana Edad,
Técnicas de Tipificación Micológica
Abstract INTRODUCTION Incidence and antifungal susceptibility of Candida spp. from two teaching public hospitals are described. METHODS The minimum inhibitory concentrations of fluconazole, voriconazole, itraconazole, and amphotericin B were determined using Clinical Laboratory Standard Institute bro...
Anfotericina B/farmacología,
Antifúngicos/farmacología,
Brasil,
Candida/clasificación,
Candida/efectos de los fármacos,
Candida/genética,
Candidiasis/microbiología,
Farmacorresistencia Fúngica,
Fluconazol/farmacología,
Hospitales Públicos,
Itraconazol/farmacología,
Pruebas de Sensibilidad Microbiana,
Persona de Mediana Edad,
Voriconazol/farmacología
BACKGROUND Sporothrix brasiliensis is the most virulent sporotrichosis agent. This species usually responds to antifungal drugs, but therapeutic failure can occur in some patients. Antifungal susceptibility tests have been performed on this species, but no clinical breakpoints (CBPs) are available. In th...
BACKGROUND Gene reporter-fluorescent cells have emerged as alternative method for drug screening. OBJECTIVE Achievement of constitutive expression of fluorescent protein GFP by Leishmania braziliensis as alternative method for drug screening. METHODS L. braziliensis-GFP was generated using Leishmania...
Abstract Amphotericin B is a fungicidal substance that is treatment of choice for most systemic fungal infections affecting as cryptococcosis the immunocompromised patients. However, severe side effects have limited the utility of this drug. The aim of this study was to evaluate the antifungal effect of ...
ABSTRACT The antifungal activity of tacrolimus in combination with antifungal agents against different fungal species has been previously reported. Here we report the in vitro interactions between tacrolimus and amphotericin B, fluconazole, itraconazole, and caspofungin against 30 clinical isolates of bo...
Anfotericina B/farmacología,
Antifúngicos/farmacología,
Inhibidores de la Calcineurina/farmacología,
Caspofungina,
Interacciones Farmacológicas,
Sinergismo Farmacológico,
Equinocandinas/farmacología,
Fluconazol/farmacología,
Itraconazol/farmacología,
Lipopéptidos/farmacología,
Pruebas de Sensibilidad Microbiana,
Tacrolimus/farmacología,
Trichosporon/efectos de los fármacos
