ABSTRACT Objectives: Paraoxonase 1 (PON1) is an enzyme that has antioxidant potential, which confers a protective effect against the atherosclerotic process. However, studies associating genetics, dietary patterns and PON1 activity in individuals with cardiovascular disease (CVD) are scarce. Thus, the a...
ABSTRACT Objective: The aim of this study was to evaluate the serum activity of PON1 in women according to SNPs L55M and T-107C and diet composition. Materials and methods: Blood and serum samples from 26 women were used. DNA extraction, PCR and digestion with restriction enzymes of the PCR fragment we...
Abstract Objective The aim of the present study was to examine the relation between the PON1 polymorphisms and recurrent pregnancy loss (RPL). Methods In a cross-sectional study, blood samples were collected from 100 females. DNA was extracted and PON1 genotypes were determined by polymerase chain re...
ABSTRACT Purpose: Paraoxonase-1 activity is associated with age-related macular degeneration. Two polymorphisms (L55M and Q192R) were shown to increase paraoxonase-1 activity and have been implicated in the development of age-related macular degeneration. The results of studies that have examined these ...
Abstract Objective: The cardioprotective enzyme paraoxonase-1 (PON1) suffers an important influence from genetic polymorphisms and nutritional factors. The aim of this study was to investigate the influence of diet, nutritional status, and the C(-107)T polymorphism on PON1 arylesterase activity in child...
ABSTRACT PURPOSE: We examined the effect of intracameral administration of cefuroxime on oxidative stress and endothelial apoptosis in rat corneal tissue. METHODS: In total, 30 rats were divided into 3 groups of 10 rats each (intracameral administration of cefuroxime 0.1 mg/0.01 mL (cefuroxime group); ...
Antibacterianos/farmacología,
Apoptosis/efectos de los fármacos,
Arildialquilfosfatasa/análisis,
Hidrolasas de Éster Carboxílico/análisis,
Caspasa 3/análisis,
Caspasa 8/análisis,
Cefuroxima/farmacología,
Córnea/efectos de los fármacos,
Córnea/metabolismo,
Córnea/patología,
Endotelio Corneal/efectos de los fármacos,
Endotelio Corneal/metabolismo,
Endotelio Corneal/patología,
Inmunohistoquímica,
Inyecciones Intraoculares,
Oxidantes/sangre,
Estrés Oxidativo/efectos de los fármacos,
Ratas Wistar,
Reproducibilidad de los Resultados
Ritta, Mauren Castro;
Baldez, Aline Marques;
Oliveira, Isabel Oliveira de;
Garcia, Driele Neske;
Souza, Paola Spiering;
Andrade, Kelvin Ruan da Silva;
Valle, Sandra Costa;
Pieniz, Simone;
Barros, Carlos Castilho;
Masternak, Michal M;
Schneider, Augusto.
ABSTRACT Objective The aims of this study were to investigate changes in serum paraoxonase 1 (PON1) activity in women at the pre and postmenopausal stages and its association with the PON1 C(-107)T polymorphism and food intake profile. Subjects and methods A cross-sectional study with female patients...
Abstract Background: The serum paraoxonase-1 (PON1) associated to HDL presents two common polymorphisms in the positions 192 and 55. These polymorphisms are considered determinant of the capacity of HDL to protect LDL from their oxidative modification. In this context, the PON1 genotype has been associ...
Arildialquilfosfatasa/genética,
Isquemia Encefálica/genética,
Predisposición Genética a la Enfermedad,
Accidente Cerebrovascular/genética,
Alelos,
Isquemia Encefálica/patología,
Estudios de Casos y Controles,
Frecuencia de los Genes,
Genotipo,
Modelos Lineales,
México,
Proyectos Piloto,
Reacción en Cadena de la Polimerasa,
Polimorfismo Genético,
Polimorfismo de Longitud del Fragmento de Restricción,
Factores de Riesgo,
Accidente Cerebrovascular/patología
Abstract Purpose: To investigate the biochemical, histopathologic, and spermatogenetic changes in the detorsionated testicle after experimental torsion and to study the antioxidant effects of pheniramine maleate and nebivolol. Methods: Twenty-four Sprague-Dawley male rats were divided into 4 groups: G...
Antagonistas Adrenérgicos beta/farmacología,
Antioxidantes/farmacología,
Arildialquilfosfatasa/sangre,
Antagonistas de los Receptores Histamínicos H1/farmacología,
Nebivolol/farmacología,
Estrés Oxidativo/efectos de los fármacos,
Feniramina/farmacología,
Ratas Sprague-Dawley,
Daño por Reperfusión/tratamiento farmacológico,
Torsión del Cordón Espermático/tratamiento farmacológico,
Torsión del Cordón Espermático/patología,
Espermatogénesis/efectos de los fármacos,
Testículo/irrigación sanguínea,
Testículo/efectos de los fármacos,
Testículo/patología,
Factores de Tiempo
OBJECTIVES: Consumption of toxic species of mushrooms may have detrimental effects and increase oxidative stress. Paraoxonase, arylesterase and glutathione-S-transferase are antioxidants that resist oxidative stress. In this study, we analyzed the changes in these enzymes during intoxication due to mushr...
Antioxidantes/análisis,
Arildialquilfosfatasa/sangre,
Hidrolasas de Éster Carboxílico/sangre,
Estudios de Casos y Controles,
Glutatión Transferasa/sangre,
Tiempo de Internación/estadística & datos numéricos,
Intoxicación por Setas/sangre,
Intoxicación por Setas/enzimología,
Estrés Oxidativo,
Valores de Referencia,
Espectrofotometría,
Estadísticas no Paramétricas
