Zhang, Xiaojun;
Wang, Changsen;
Xu, Hao;
Cai, Shuyun;
Liu, Keyu;
Li, Simeng;
Chen, Linming;
Shen, Siman;
Gu, Xiaoxia;
Tang, Jing;
Xia, Zhengyuan;
Hu, Zhe;
Ma, Xiaotang;
Zhang, Liangqing.
BACKGROUND: Ischemia-reperfusion (IR) induces increased release of extracellular vesicles in the heart and exacerbates myocardial IR injury. We have previously shown that propofol attenuates hypoxia/reoxygenation (HR)-induced injury in human umbilical vein endothelial cells (HUVECs) and that microvesicle...
BACKGROUND: The distinct arterial and venous cell fates are dictated by a combination of various genetic factors which form diverse types of blood vessels such as arteries, veins, and capillaries. We report here that YULINK protein is involved in vasculogenesis, especially venous formation. METHODS: In t...
Lee, Wonhwa;
Kim, Ji-Eun;
Yang, Sumin;
Lee, Bong-Seon;
Cho, Soo-Hyun;
Lee, Jee-Hyun;
Choi, Ga-Eun;
Park, Eui Kyun;
Song, Gyu-Yong;
Bae, Jong-Sup.
Abstract RGX-365 is the main fraction of black ginseng conmprising protopanaxatriol (PPT)-type rare ginsenosides (ginsenosides Rg4, Rg6, Rh4, Rh1, and Rg2). No studies on the antiseptic activity of RGX-365 have been reported. High mobility group box 1 (HMGB1) is recognized as a late mediator of sepsis, a...
Abstract In an attempt to increase molecular stability and provide controlled release, vascular endothelial growth factor (VEGF) was encapsulated into polycaprolactone (PCL) nanoparticles. Both VEGF-free and VEGF-loaded PCL nanoparticles were formulated by w/o/w double emulsion of the dichloromethane-wat...
SUMMARY OBJECTIVE: In this study, we aimed at investigating the role of isoleucyl-tRNA synthetase in the growth, migration, and angiogenesis of human umbilical vein endothelial cells and the underlying molecular mechanism. METHODS: To assess the role of isoleucyl-tRNA synthetase, we silenced isoleucyl-...
BACKGROUND: Atherosclerosis (AS) is the most common type in cardiovascular disease. Due to its complex pathogenesis, the exact etiology of AS is unclear. circRNA has been shown to play an essential role in most diseases. However, the underlying mechanism of circRNA in AS has been not understood clearly. ...
Aterosclerosis/genética,
MicroARNs/genética,
Apoptosis/genética,
Histona Desacetilasa 1/genética,
Proliferación Celular,
Células Endoteliales de la Vena Umbilical Humana,
Inflamación/genética,
Lipoproteínas LDL,
Proteínas Nucleares,
ARN Circular,
Transactivadores
Atherosclerosis could be induced by multiple factors, including hypertension, hyperlipidemia, and smoking, and its pathogenesis has not been fully elucidated. MicroRNAs have been shown to possess great anti-atherosclerotic potential, but the precise function of miR-92a-3p in atherosclerosis and its poten...
The study evaluated the effect of the supernatant of placental explants from preeclamptic (PE) and normotensive (NT) pregnant women after tissue treatment with or without vitamin D (VD) on oxidative stress and nitric oxide (NO) bioavailability in human umbilical vein endothelial cells (HUVEC). Placental ...
OBJECTIVES: Hypoxia leads to endothelial cell inflammation, apoptosis, and damage, which plays an important role in the complications associated with ischemic cardiovascular disease. As an oxidoreductase, p66Shc plays an important role in the regulation of reactive oxygen species (ROS) production and apo...
Zhu, Qing;
Li, Jingchao;
Wu, Qi;
Cheng, Yongxia;
Zheng, Huizhe;
Zhan, Tao;
Wang, Hongwei;
Yang, Yue;
Wang, Hongyan;
Liu, Ye;
Guo, Sufen.
BACKGROUND: LincRNAs have been revealed to be tightly associated with various tumorigeneses and cancer development, but the roles of specific lincRNA on tumor-related angiogenesis was hardly studied. Here, we aimed to investigate whether linc-OIP5 in breast cancer cells affects the angiogenesis of HUVECs...
Proteínas Adaptadoras Transductoras de Señales/metabolismo,
Neoplasias de la Mama/patología,
Células Endoteliales de la Vena Umbilical Humana/citología,
Neuropilina-1/metabolismo,
Receptores Notch/metabolismo,
Factores de Transcripción/metabolismo,
Microambiente Tumoral,
Neoplasias de la Mama/metabolismo,
Western Blotting,
Línea Celular Tumoral,
Inmunohistoquímica,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Transducción de Señal
