SUMMARY: Esophageal cancer is one of the most aggressive gastrointestinal cancers. Invasion and metastasis are the main causes of poor prognosis of esophageal cancer. SPRY2 has been reported to exert promoting effects in human cancers, which controls signal pathways including PI3K/AKT and MAPKs. However,...
SUMMARY: This study is to investigate the effect of survivin down-regulation by Egr1-survivin shRNA combined with radiotherapy on the apoptosis and radiosensitivity of esophageal squamous cell carcinoma ECA109 and KYSE150 cells. ECA109 and KYSE150 cells were transfected with Egr1-survivin shRNA, and then...
Neoplasias Esofágicas/terapia,
Carcinoma de Células Escamosas de Esófago/terapia,
Neoplasias Esofágicas/genética,
Carcinoma de Células Escamosas de Esófago/genética,
Transfección,
Survivin,
Fármacos Sensibilizantes a Radiaciones,
Neoplasias Esofágicas/radioterapia,
Carcinoma de Células Escamosas de Esófago/radioterapia,
Línea Celular Tumoral/efectos de la radiación,
ARN Mensajero,
Western Blotting,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Regulación hacia Abajo,
Apoptosis,
Citometría de Flujo,
Caspasa 3,
Caspasa 9,
ARN Interferente Pequeño,
Terapia Combinada,
Tolerancia a Radiación,
Proteína 1 de la Respuesta de Crecimiento Precoz
Purpose: To investigate the role and mechanism of β1,3-N-acetylglucosaminyltransferase-3 gene (B3GNT3) in esophageal cancer (ESCA). Methods: The starBase database was used to evaluate the expression of B3GNT3. B3GNT3 function was measured using KYSE-30 and KYSE-410 cells of esophageal squamous cell carc...
Purpose: Esophageal squamous cell carcinoma (ESCC) is characterized by early metastasis and late diagnosis. miR-29c-3p is confirmed to repress angiogenesis in multiple tumor types. Yet, the functions of miR-29c-3p in the mechanism of ESCC angiogenesis, which were not sufficiently explored previously, wer...
ABSTRACT Background: Currently, persistent human papillomavirus (HPV) infection has been related in some geographic regions as a risk factor for esophageal squamous cell carcinoma. It results in the immunoexpression of the p16 protein, which has been used as marker of the oncogenic lineage by this etiol...
ABSTRACT Background Multimodal therapy with neoadjuvant chemoradiotherapy, followed by esophagectomy has offered better survival results, compared to isolated esophagectomy, in advanced esophageal cancer. In addition, patients who have a complete pathological response to neoadjuvant treatment presented...
Abboud, H S;
Camuzi, D;
Rapozo, D C;
Fernandes, P V;
Nicolau-Neto, P;
Guaraldi, S;
Simão, T A;
Ribeiro Pinto, L F;
Gonzaga, I M;
Soares-Lima, S C.
Esophageal squamous cell carcinoma (ESCC) is among the ten most frequent and deadly cancers, without effective therapies for most patients. More recently, drugs targeting deregulated growth factor signaling receptors have been developed, such as HGF-MET targeted therapy. We assessed MET and HGF genetic a...
OBJECTIVE: The long non-coding RNA (lncRNA) KCNQ1 overlapping transcript 1 (KCNQ1OT1) exerts vital regulatory functions in diverse tumors. However, the biological function of KCNQ1OT1 in esophageal squamous cell carcinoma (ESCC) remains unclear. METHODS: KCNQ1OT1 expression was detected in ESCC tissues ...
Xue, Nannan;
Zhou, Runze;
Deng, Ming;
Li, Yitong;
Hu, Yong;
Gao, Liang;
Zhang, Yunbo;
Song, Xiangyu;
Liu, Junqi;
Fan, Ruitai.
OBJECTIVES: Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors in China. Intensity-modulated radiation therapy and volume-modulated arc therapy have become the main treatments for esophageal carcinoma; however, side effects caused by radiotherapy greatly impact the quali...
ABSTRACT Background: Fibrinogen (Fib) to albumin (ALB) fibrinogen-to-albumin ratio as a prognostic index for esophageal cancer has been confirmed. A novel prognostic index was initially proposed with fibrinogen to prealbumin ratio (FPR) in patients with resectable esophageal squamous cell carcinoma (ESC...
