La señalización celular es un complejo mecanismo molecular que consiste en la transferencia de información proveniente de un ambiente externo celular, que es recibida, traducida y convertida en una respuesta interna, permitiendo comunicar a la célula con su entorno y con otras células. A nivel intra...
ABSTRACT Cysteine proteinases are well-known virulence factors of Leishmania spp. with demonstrated actions in both experimental mouse infection and human infection. However, studies on these enzymes in canine leishmaniasis are scarce. Here, we show, for the first time, the reactivity of sera from dogs l...
Phoneutria nigriventer spider venom contains several cysteine-rich peptide toxins that act on different ion channels. Despite extensive studies on its venom and description of cDNA sequences of several of its toxin precursors, the gene structure of these toxins remains unknown. Methods: Genomic regions ...
Introdução: A adesão da resina composta à dentina ocorre pela formação da camada híbrida. Assim, sua degradação ocasiona a perda da resistência de união na interface resina/dentina, influenciando na longevidade da restauração. Após o condicionamento ácido e aplicação do sistema adesivo n...
Abstract Purpose: To investigate the participation of cysteinyl leukotrienes in the pathophysiology of oral mucositis. Methods: Oral mucositis was induced in hamsters using 5-fluorouracil (5-FU; 60 and 40 mg/kg; i.p., on days 1 and 2, respectively, and with excoriations in jugal mucosa on day 4). Monte...
BACKGROUND: Aged garlic extract (AGE) and its main constituent S-allylcysteine (SAC) are natural antioxidants with protective effects against cerebral ischemia or cancer, events that involve hypoxia stress. Cobalt chloride (CoCl2) has been used to mimic hypoxic conditions through the stabilization of the...
Antioxidantes/farmacología,
Apoptosis/efectos de los fármacos,
Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/efectos de los fármacos,
Cisteína/análogos & derivados,
Ajo/química,
Extractos Vegetales/farmacología,
Hipoxia de la Célula/efectos de los fármacos,
Supervivencia Celular/efectos de los fármacos,
Cisteína/farmacología,
Especies Reactivas de Oxígeno/análisis,
Análisis de Varianza,
Células Cultivadas,
Cobalto,
Citometría de Flujo,
Formazáns,
Células PC12,
Sales de Tetrazolio
Background Hepcidins, a kind of cysteine-rich antimicrobial peptides, play important roles in host immunological processes and iron regulation, which have been identified from several fish species. The rare minnow (Gobiocypris rarus), an endemic cyprinid fish in China, has been used extensively as model ...
BACKGROUND: In recent years, the desire to adopt a healthy diet has drawn attention to legume seeds and food products derived from them. Mash bean is an important legume crop used in Pakistan however a systematic mapping of the chemical composition of mash bean seeds is lacking. Therefore seeds of four m...
Productos Agrícolas/química,
Fabaceae/química,
Semillas/química,
Antioxidantes/metabolismo,
Productos Agrícolas/metabolismo,
Cisteína/análisis,
Fabaceae/metabolismo,
Flavonoides/análisis,
Productos Finales de Glicación Avanzada/metabolismo,
Monofenol Monooxigenasa/antagonistas & inhibidores,
Niacina/análisis,
Fenoles/análisis,
Extractos Vegetales/química,
Sustancias Reductoras/metabolismo,
Riboflavina/análisis,
Semillas/metabolismo,
Esteroles/análisis,
Taninos/análisis,
Tiamina/análisis,
Tocoferoles/análisis,
Oligoelementos/análisis,
Depuradores de Radicales Libres,
Valor Nutritivo,
Pakistán
Background Echinometra lucunter is a common American sea urchin responsible for the majority of the marine accidents in Brazil. Although not lethal, these accidents are reported to be extremely painful. Recently, our group described the presence of toxins in its spines that contribute to the pathological...
