Abstract In the present study, the application of ultra-high performance liquid chromatography-tandem mass spectrometry allowed us to study of known-as well as hitherto unknown-trimetazidine (TMZ) metabolites in human urine and to propose their renal excretion profiles. Urine samples from a healthy volun...
Dunjić, Momir;
Krstić, Dejan;
Živković, Jovan;
Cvetković, Saša;
Dunjić, Katarina;
Mirković, Miloš;
Ranković, Goran;
Ranković, Branislava;
Sokolović, Danka;
Sokolović, Dušan.
Abstract Carbon tetrachloride (CCl4) represents an organic chemical that causes reactive oxygen species derived organ disturbances including male infertility. Melatonin (MLT) is a neurohormone with strong antioxidant capacity, involved in numerous physiological processes. In this study we evaluated the c...
Phosphodiesterase-5 inhibitors (PDE-5Is) exert positive effects on bone healing and mineralization by activation the nitric oxide/cyclic guanosine monophosphate/protein kinase-G (NO/cGMP/PKG) signaling pathway. In this study, the effects of zaprinast and avanafil, two PDE-5Is, on the NO signaling pathway...
Abstract Tolosa-Hunt syndrome is a painful ophthalmoplegia caused by non-specific granulomatous inflammation, corticoid-sensitive, of the cavernous sinus. The etiology is unknown. Recurrences are common. The diagnosis is made by exclusion, and a variety of other diseases involving the orbital apex, super...
This study was carried out in order to compare the relative bioavailability of two different formulations containing 400 mg of acetaminophen + 4 mg of phenylephrine hydrochloride + 4 mg of chlorpheniramine maleate, Test formulation (Cimegripe®) and Reference formulation (Resfenol®) in 84 healthy volunt...
Acetaminofén/análisis,
Fenilefrina/análisis,
Clorfeniramina/análisis,
Cápsulas/clasificación,
Disponibilidad Biológica,
Espectrometría de Masas/métodos,
Absorción/efectos de los fármacos,
Dosis Única,
Espectrometría de Masas en Tándem/métodos,
Estudios Cruzados,
Ayuno/efectos adversos,
34628,
Voluntarios Sanos/clasificación
Zhang, Tan;
Zhang, Minjie;
Zu, Lian;
Wang, Qian;
Wang, Qi;
Wang, Wei;
Wang, Yitong;
Zang, Yannan;
Xie, Zhenwei;
Chen, Shi;
Wang, Mei;
Zheng, Qingshan;
Li, Zhanguo;
Chen, Guihong;
Fang, Yi.
T0001 is the first mutant of etanercept with a higher affinity to tumor necrosis factor α (TNF-α) than etanercept. In order to investigate the safety and tolerability of T0001, a study was carried out in healthy Chinese subjects. A first-in-human, dose escalation study was conducted in healthy Chinese ...
Seguridad,
Dosis Única/efectos de los fármacos,
Etanercept/análogos & derivados,
Factor de Necrosis Tumoral alfa/clasificación,
Artritis Reumatoide/patología,
Electrocardiografía,
Examen Físico,
Pueblo Asiatico/clasificación,
Inyecciones Subcutáneas/clasificación,
Reacción en el Punto de Inyección,
Técnicas de Laboratorio Clínico,
Voluntarios
ABSTRACT Repirinast is a new, synthetic, disodium cromoglycate-like antiallergic agent for oral administration in humans. This study evaluated the safety, tolerability and pharmacokinetics of repirinast tablets in healthy Chinese volunteers. This was a phase I, open-label, randomized, single- and multipl...
Introducción: el dolor posoperatorio del hemiabdomen superior es intenso y su control es imprescindible para evitar complicaciones.
Objetivos: evaluar la eficacia analgésica y seguridad de dosis única de morfina intratecal en el posoperatorio de la cirugía de hemiabdomen superior de gran envergadura....
Describir la experiencia de nuestro grupo con el esquema de antibioticoterapia profiláctica en pacientes sometidos a cirugía bariátrica. Métodos: Trabajo prospectivo y descriptivo, con una población de 164 pacientes sometidos a cirugías bariátricas primarias y revisionales en el lapso enero 2014 ...
Average bioequivalence of two 500 mg levofloxacin formulations available in Brazil, Tavanic(c) (Sanofi-Aventis Farmacêutica Ltda, Brazil, reference product) and Levaquin(c) (Janssen-Cilag Farmacêutica Ltda, Brazil, test product) was evaluated by means of a randomized, open-label, 2-way crossover study ...
