Results: 10

Studies of Mucosal Irritation and Cellular Uptake Mechanisms of Xingnaojing Nanoemulsion

Abstract Xingnaojing (XNJ) injection was used to treat pneumonia and stroke in clinic in China, but with poor patient compliance. Xingnaojing nanoemulsion for intranasal delivery was developed to improve it. This article tried to evaluate the mucosal irritation of Xingnaojing nanoemulsion and investigate...

Morphology and morphogenesis of SARS-CoV-2 in Vero-E6 cells

Mem. Inst. Oswaldo Cruz; 116 (), 2021
BACKGROUND The coronaviruses (CoVs) called the attention of the world for causing outbreaks of severe acute respiratory syndrome (SARS-CoV), in Asia in 2002-03, and respiratory disease in the Middle East (MERS-CoV), in 2012. In December 2019, yet again a new coronavirus (SARS-CoV-2) first identified in ...

El síndrome urémico hemolítico y manejo renal de proteínas
Hemolytic uremic syndrome and renal handling of proteins

El síndrome urémico hemolítico (SUH) está definido por la tríada de anemia hemolítica microangiopática, trombocitopenia e insuficiencia renal aguda. En Argentina constituye la primera causa de insuficiencia renal aguda en pediatría. Aproximadamente, del 2% al 4% de los pacientes mueren durante la...

Uptake of DNA by cancer cells without a transfection reagent

Biol. Res; 50 (), 2017
BACKGROUND: Cancer cells exhibit elevated levels of glucose uptake and may obtain pre-formed, diet-derived fatty acids from the bloodstream to boost their rapid growth; they may also use nucleic acid from their microenvironment. The study of processing nucleic acid by cancer cells will help improve the u...

Sortin2 enhances endocytic trafficking towards the vacuole in Saccharomyces cerevisiae

Biol. Res; 48 (), 2015
BACKGROUND: A highly regulated trafficking of cargo vesicles in eukaryotes performs protein delivery to a variety of cellular compartments of endomembrane system. The two main routes, the secretory and the endocytic pathways have pivotal functions in uni- and multi-cellular organisms. Protein delivery an...

Calicreína plasmática de rato e ativador tecidual recombinate de plasmogênio competem na ligaçäo a células hepáticas: estudo em ratos normais e submetidos a diferentes modelos de lesäo hepática

Nesta tese comparamos características de depuração da calicreína plasmática de rato (RPK) e do ativador tecidual do plasminogênio (tPA) em modelo experimental de perfusão de ligado isolado de rato e em células hepáticas isoladas. Especificamente testamos a hipótese destas duas proteínas compet...

Enfermedad de Chagas congénita

Refiere estudios realizados por investigadores argentinos sobre Chagas congénito en modelos experimentales animales (sobre pasaje transplacentario del Trypanosoma cruzi, lesiones placentarias, actividad enzimática), y en humanos (en embarazadas y sus hijos): estudios enzimáticos e inmunológicos (infe...