Abstract In the present study, the application of ultra-high performance liquid chromatography-tandem mass spectrometry allowed us to study of known-as well as hitherto unknown-trimetazidine (TMZ) metabolites in human urine and to propose their renal excretion profiles. Urine samples from a healthy volun...
Abstract Dasatinib, a potent oral multi-targeted kinase inhibitor against Src and Bcr-Abl, can decrease inflammatory response in sepsis. A simple and cost-effective method for determination of an effective dose dasatinib was established. This method was validated in human plasma, with the aim of reducing...
Abstract The flavonoids and xanthones present in the ethanol extracts of leaves and stems of Fridericia samydoides showed that anti-dengue activities in vitro were investigated qualitatively by liquid chromatography-ultraviolet-mass spectrometry in series. Nineteen flavones and fifteen xanthones were det...
Abstract This work reports the study of the potential application of Zn/TiO2 catalysts, obtained by the sol-gel method, in processes of environmental decontamination through the reactions of photodegradation of textile dye, followed by electrospray mass spectrometry. The catalysts synthesis was performed...
Espectrometría de Masas en Tándem/métodos,
Colorantes,
Dominio Catalítico,
Descontaminación/métodos,
Biodegradación Ambiental,
Microscopía Electrónica de Rastreo,
Aguas Residuales,
Catálisis,
Compuestos Azo/toxicidad,
Espectrometría de Masa por Ionización de Electrospray,
Restauración y Remediación Ambiental/métodos,
Fotoquímica,
Fotobiorreactores,
Textiles/toxicidad,
Modelos Teóricos
This study was carried out in order to compare the relative bioavailability of two different formulations containing 400 mg of acetaminophen + 4 mg of phenylephrine hydrochloride + 4 mg of chlorpheniramine maleate, Test formulation (Cimegripe®) and Reference formulation (Resfenol®) in 84 healthy volunt...
Acetaminofén/análisis,
Fenilefrina/análisis,
Clorfeniramina/análisis,
Cápsulas/clasificación,
Disponibilidad Biológica,
Espectrometría de Masas/métodos,
Absorción/efectos de los fármacos,
Dosis Única,
Espectrometría de Masas en Tándem/métodos,
Estudios Cruzados,
Ayuno/efectos adversos,
34628,
Voluntarios Sanos/clasificación
Abstract Background Current evidence suggests that upregulation of polyamines system plays a role both in cognitive deficit and synaptic loss observed in Alzheimer's disease (AD). Objective The aim of this study was to determine the plasmatic concentration of polyamines in mild cognitive impairment (...
Poliaminas/sangre,
Disfunción Cognitiva/fisiopatología,
Enfermedad de Alzheimer/fisiopatología,
Cromatografía Liquida/métodos,
Espectrometría de Masas en Tándem/métodos,
Biomarcadores/sangre,
Espermina/sangre,
Metabolómica/métodos,
Poliaminas/metabolismo,
Enfermedad de Alzheimer/diagnóstico,
Disfunción Cognitiva/diagnóstico,
Espermidina/sangre,
Ornitina/sangre,
Putrescina/sangre
ABSTRACT Matrix Assisted Laser Desorption/Ionization and Time of Flight mass spectrometry (MALDI-TOF MS) is a powerful tool for the identification of bacteria through the detection and analysis of their proteins or fragments derived from ribosomes. Slight sequence variations in conserved ribosomal protei...
Técnicas de Tipificación Bacteriana/métodos,
Brasil,
ADN Bacteriano/genética,
Leptospira/química,
Leptospira/clasificación,
Leptospira/genética,
Leptospira/aislamiento & purificación,
Leptospirosis/microbiología,
ARN Ribosómico 16S/genética,
Espectrometría de Masa por Láser de Matriz Asistida de Ionización Desorción/métodos,
Espectrometría de Masas en Tándem/métodos
As bifenilas policloradas (PCBs) são um grupo de compostos hidrocarbonetos halogenados aromáticos, bioacumulativos em organismos vivos e persistente no ambiente. Além da atividade disruptora endócrina, os PCBs podem aumentar os níveis de espécies reativas de oxigênio (ROS), levando ao estresse oxi...
ABSTRACT A simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the quantification of cabozantinib (CZ) in human plasma using cabozantinib-d4 (CZD4) as an internal standard (IS). Chromatographic separation was performed on Xbridge C18, 50 x 4.6...
El-Aziz, Tarek Mohamed Abd;
Khoury, Sawsan Al;
Jaquillard, Lucie;
Triquigneaux, Mathilde;
Martinez, Guillaume;
Bourgoin-Voillard, Sandrine;
Sève, Michel;
Arnoult, Christophe;
Beroud, Rémy;
Waard, Michel De.
Sperm contains a wealth of cell surface receptors and ion channels that are required for most of its basic functions such as motility and acrosome reaction. Conversely, animal venoms are enriched in bioactive compounds that primarily target those ion channels and cell surface receptors. We hypothesized, ...
