SUMMARY: The aim of the present work was to study the closer effect of clomiphene citrate on the ultrastructure of the testis of adult albino rats to provide a basis for optimizing this drug in the treatment of male infertility. The testes were removed from both groups under anesthesia and then prepared ...
Abstract Testicular damage is one of the most hazardous effects of chemotherapy as it is frequently associated with oligozoospermia and azoospermia. This study aimed at evaluating the protective effect of melatonin in a rat model of busulfan-induced testicular injury. Rats were divided into four groups: ...
SUMMARY: The study reported the influence of the high and acute dose of Letrozole on the testis morphology in paca (Cuniculus paca), an aromatase inhibitor that reduces the endogenous estrogen, the essential hormone for spermatogenesis. Morphological changes were observed in seminiferous epithelium with ...
Hypoxia hypobaric (HH) can cause alterations at testicular level, with temperature increase, intrascrotal alteration and deterioration of spermatogenesis. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ketoprofen have anti-angiogenic properties, and can decrease testicular abnormalities. The objec...
Cetoprofeno/farmacología,
Cetoprofeno/administración & dosificación,
Hipoxia/fisiopatología,
Testículo/efectos de los fármacos,
Testículo/lesiones,
Espermatogénesis/efectos de los fármacos,
Antiinflamatorios no Esteroideos/farmacología,
Antiinflamatorios no Esteroideos/administración & dosificación,
Hematócrito,
Reticulocitos/efectos de los fármacos,
Túbulos Seminíferos/efectos de los fármacos,
Neovascularización Patológica
ABSTRACT Introduction Chronic hyperglycemia is caused by diabetes mellitus-committed genital morphophysiology, and oxidative stress is one of the main factors involved in this process. Alpha lipoic acid (ALA) can prevent metabolic and morphological changes in diabetic individuals. Objectives In prese...
Antioxidantes/farmacología,
Diabetes Mellitus Experimental/patología,
Diabetes Mellitus Experimental/fisiopatología,
Epidídimo/efectos de los fármacos,
Epidídimo/patología,
Inmunohistoquímica,
Distribución Aleatoria,
Ratas Wistar,
Reproducibilidad de los Resultados,
Células de Sertoli,
Recuento de Espermatozoides,
Motilidad Espermática/efectos de los fármacos,
Espermatogénesis/efectos de los fármacos,
Espermatogénesis/fisiología,
Espermatozoides/efectos de los fármacos,
Espermatozoides/fisiología,
Testículo/efectos de los fármacos,
Testículo/patología,
Testículo/fisiopatología,
Ácido Tióctico/farmacología
Abstract Purpose: To investigate the biochemical, histopathologic, and spermatogenetic changes in the detorsionated testicle after experimental torsion and to study the antioxidant effects of pheniramine maleate and nebivolol. Methods: Twenty-four Sprague-Dawley male rats were divided into 4 groups: G...
Antagonistas Adrenérgicos beta/farmacología,
Antioxidantes/farmacología,
Arildialquilfosfatasa/sangre,
Antagonistas de los Receptores Histamínicos H1/farmacología,
Nebivolol/farmacología,
Estrés Oxidativo/efectos de los fármacos,
Feniramina/farmacología,
Ratas Sprague-Dawley,
Daño por Reperfusión/tratamiento farmacológico,
Torsión del Cordón Espermático/tratamiento farmacológico,
Torsión del Cordón Espermático/patología,
Espermatogénesis/efectos de los fármacos,
Testículo/irrigación sanguínea,
Testículo/efectos de los fármacos,
Testículo/patología,
Factores de Tiempo
ABSTRACT Equigan is an anabolic steroid that has been developed for veterinary use and derived from endogenous sex hormone testosterone that plays a key role in the development of male reproductive tissue as well as in puberty and spermatogenesis. The current study is aimed to investigate the possible pr...
SUMMARY: Morphine is one of the naturally occurring phenanthrene alkaloids of opium that induces adverse effects on male reproductive system. Resveratrol is a phytoestrogen and antioxidant of red grape. The main goal is to investigate whether resveratrol could inhibit adverse effects of morphine on sperm...
Finasteride is a 5-α reductase inhibitor that is widely used in the management of benign prostate hyperplasia and male pattern hair loss. It is well known that these agents improve the quality of life in men suffering from these conditions. However, they are associated with some transient and even p...
Finasterida/efectos adversos,
Inhibidores de 5-alfa-Reductasa/efectos adversos,
Inhibidores de 5-alfa-Reductasa/uso terapéutico,
Alopecia/tratamiento farmacológico,
Glucemia/metabolismo,
Disfunción Eréctil/inducido químicamente,
Finasterida/uso terapéutico,
Metabolismo de los Lípidos/efectos de los fármacos,
Hiperplasia Prostática/tratamiento farmacológico,
Neoplasias de la Próstata/prevención & control,
Espermatogénesis/efectos de los fármacos
The restriction of the mechanisms of cell proliferation in murine seminiferous epithelium, in terms of induction of programmed cell death until recently has not been fully analyzed. The aim of this work was to assess the effect of Malathion (MP) on testicular morphology and function in mouse spermatogene...
