Taha, Medhat;
Ibrahim, Mohie Mahmoud;
Elazab, Sara T;
Badawy, Alaa. M;
Abdelsalam, Ramy A;
Saati, Abdullah A;
Qusty, Naeem F;
Babateen, Omar;
Abdelbagi, Omer;
Hendawy, M.
SUMMARY: One of the reasons for acute kidney damage is renal ischemia. Nevertheless, there are limited protective and therapeutic approaches for this problem. Diacerein is an anti-inflammatory drug characterized by numerous biological activities. We aimed to determine the ameliorative impact of diacerein...
Antraquinonas/administración & dosificación,
Antiinflamatorios/administración & dosificación,
Daño por Reperfusión/tratamiento farmacológico,
Antraquinonas/inmunología,
Células Dendríticas/efectos de los fármacos,
Apoptosis/efectos de los fármacos,
Enfermedades Renales/tratamiento farmacológico,
Daño por Reperfusión/inmunología,
Enfermedades Renales/inmunología,
Inyecciones Intraperitoneales,
FN-kappa B/metabolismo,
Receptor Toll-Like 4/metabolismo,
Transducción de Señal,
Estrés Oxidativo,
Inflamación,
Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo,
Interleucina-1beta/metabolismo,
Citometría de Flujo,
d0201690,
d0200110
Cui, Xinyuan;
Li, Yifu;
Yuan, Shuguang;
Huang, Yao;
Chen, Xiaojun;
Han, Yachun;
Liu, Zhiwen;
Li, Zheng;
Xiao, Yang;
Wang, Youliang;
Sun, Lin;
Liu, Hong;
Zhu, Xuejing.
BACKGROUND: Alpha-kinase 1 (ALPK1) is a master regulator in inflammation and has been proved to promote renal fibrosis by promoting the production of IL-1β in diabetic nephropathy (DN) mice. Pyroptosis is involved in high glucose (HG)-induced tubular cells injury, characterized by activation of Gasdermi...
BACKGROUND: Isolation of nuclei or nuclear proteins is a prerequisite for western blot, nuclear proteome profiling, and other evaluations of nuclear proteins. Here, we developed a simple method for in situ isolation of nuclei or nuclear proteins by in situ removing the extranuclear part of adherent cells...
SUMMARY: Diabetes is a metabolic disorder characterized by high blood sugar levels and it causes complications in many systems, including the reproductive system. As a result of diabetic conditions, one of the mechanisms that can cause repression of reproductive activity is testicular oxidant stress. The...
ABSTRACT Purpose To demonstrate the effect of IL-33 on the macrophage pyroptosis in mice with sepsis through the NF-kB/p38 MAPK signal pathway. Methods In total, 24 C57BL/6 mice were divided into the sham operation group (sham) and the cecal ligation and puncture group (CLP). After CLP, 24 IL-33-/- mic...
OBJECTIVES: To investigate the role of miR-139-5p and the TLR4/MyD88/NF-κB signaling pathway in acute lung injury in septic mice. METHOD: A total of 140 healthy male SPF C57BL/6 mice were divided into seven groups, i.e., Normal, Control, NC, miR-139-5p mimic, miR-139-5p inhibitor, TAK-242, and miR-...
ABSTRACT Purpose: Testicular germ cells tumor (TGCT) are associated with a high cure rate and are treated with platinum-based chemotherapy. However, a group of testicular cancer patients may have a very unfavorable evolution and insensitivity to the main therapeutic agent chemotherapy (CT) cisplatin. Th...
Protocolos de Quimioterapia Combinada Antineoplásica,
Cisplatino,
Reparación del ADN,
Proteínas de Unión al ADN,
Resistencia a Antineoplásicos/fisiología,
Endonucleasas,
Proteínas de Unión al GTP/metabolismo,
Neoplasias Pulmonares,
FN-kappa B/metabolismo,
Pronóstico,
Estudios Retrospectivos,
Neoplasias Testiculares,
Transglutaminasas/metabolismo
H1N1 virus-induced excessive inflammatory response contributes to severe disease and high mortality rates. There is currently no effective strategy against virus infection in lung. The present study evaluated the protective roles of a natural compound, lapiferin, in H1N1 virus-induced pulmonary inflammat...
Acne is a kind of common, chronic skin condition caused by the inflammation of the sebaceous glands in hair follicles. Recent studies have demonstrated that baicalin (BA) possesses potential anti-inflammatory properties. In this study, we evaluated the anti-inflammatory activity of BA in vitro and in viv...
Dermatitis/tratamiento farmacológico,
Flavonoides,
Inflamasomas,
Inflamación/inducido químicamente,
Inflamación/tratamiento farmacológico,
Interleucina-1beta/metabolismo,
Sistema de Señalización de MAP Quinasas,
FN-kappa B/metabolismo,
Proteína con Dominio Pirina 3 de la Familia NLR,
Propionibacterium acnes/metabolismo,
Ratas Sprague-Dawley,
Transducción de Señal
In this study, we aimed to analyze the anti-cancer effects of β-elemene combined with paclitaxel for ovarian cancer. RT-qPCR, MTT assay, western blot, flow cytometry, and immunohistochemistry were used to analyze in vitro and in vivo anti-cancer effects of combined treatment of β-elemene and pa...
Apoptosis/efectos de los fármacos,
Western Blotting,
Línea Celular Tumoral,
Movimiento Celular/efectos de los fármacos,
Proliferación Celular/efectos de los fármacos,
Inmunohistoquímica,
Ratones Endogámicos BALB C,
FN-kappa B/efectos adversos,
FN-kappa B/metabolismo,
Neoplasias Ováricas/tratamiento farmacológico,
Neoplasias Ováricas/metabolismo,
Neoplasias Ováricas/patología,
Paclitaxel/administración & dosificación,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Sesquiterpenos/administración & dosificación,
Transducción de Señal,
Transfección
