Abstract Objective Our goal was to evaluate the modulation of the synovial fluid cells (SFC) from patients with and without osteoarthritis (OA) by bone morphogenetic protein 4 (BMP-4), Smad-3 and transforming growth factor beta (TGF-β). Methods Synovial fluid was collected from patients submitted ...
Purpose:
To evaluate fibrosis formation and number of macrophages in capsules formed around textured implants without and with mesh coverage.
Methods:
Fibrosis was analyzed through transforming growth factor-beta 1 (TGF-β1) immunomarker expression and the number of macrophages through CD68 percentage o...
Abstract Hepatocellular carcinoma (HCC) is the most common primary liver tumor. Hexachlorobenzene (HCB) is an endocrine disruptor and a liver tumor promoter. Deregulation of thyroid hormone (TH) homeostasis may play a significant role in early neoplastic transformation. The aim of this study was to evalu...
Peres, Karina Colombera;
Teodoro, Larissa;
Amaral, Laís Helena Pereira;
Teixeira, Elisângela Souza;
Barreto, Icléia Siqueira;
Freitas, Leandro Luiz Lopes de;
Maximo, Valdemar;
Assumpção, Lígia V. Montalli;
Bufalo, Natassia Elena;
Ward, Laura Sterian.
ABSTRACT Objective: Abnormalities involving the TGFB1 gene and its receptors are common in several types of cancer and often related to tumor progression. We investigated the role of single nucleotide polymorphisms (SNP) in the susceptibility to cancer, their impact on its features, as well as the role ...
Introdução: O câncer de mama é a neoplasia mais comum em mulheres. A maioria deles é
diagnosticada em estágios iniciais, quando o tratamento visa a cura. Mas apesar dos avanços no tratamento, metástases à distância podem ocorrer. A biópsia das lesões metastáticas é recomendada para confirma...
As glândulas salivares são estruturas formadas por um sistema de ductos e ácinos responsáveis por secretar saliva. Apesar de raros, os tumores de glândulas salivares compreendem um grupo heterogêneo de lesões, apresentando diferentes características histológicas, sendo de difícil classificaçã...
ABSTRACT Purpose Herein we evaluated the effects of platelet concentrate (PC) and platelet-poor plasma (PPP) on bone repair using noncritical defects in the calvaria of rabbits and compared them to the presence of TGF-β1 and osteocalcin on reparative sites. Methods Five noncritical defects of 8.7 ...
OBJECTIVES: To investigate the efficacy and potential molecular mechanism of Huangkui capsule in combination with leflunomide (HKL) for the treatment of immunoglobulin A nephropathy (IgAN) METHODS: IgAN rat models were constructed by treating rats with bovine serum albumin, lipopolysaccharide, and tetra...
BACKGROUND: PGF2α is essential for the induction of the corpus luteum regression which in turn reduces progesterone production. Early growth response (EGR) proteins are Cys2-His2-type zinc-finger transcription factor that are strongly linked to cellular proliferation, survival and apoptosis. Rapid eleva...
Búfalos,
Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Espaciadas,
Cuerpo Lúteo/fisiología,
Dinoprost/farmacología,
Proteína 1 de la Respuesta de Crecimiento Precoz/fisiología,
Luteólisis,
Células Cultivadas,
Cuerpo Lúteo/citología,
Regulación de la Expresión Génica,
Transducción de Señal,
Factor de Crecimiento Transformador beta1/fisiología
Fibrosis caused by the increase in extracellular matrix in cardiac fibroblasts plays an important role in the occurrence and development of atrial fibrillation (AF). The aim of this study was to investigate the role of hsa-miR-4443 in AF, human cardiac fibroblast (HCFB) proliferation, and extracellular m...
