Abstract Background The precise underlying mechanism of antioxidant effects of dexmedetomidine-induced neuroprotection against cerebral ischemia has not yet been fully elucidated. Activation of Nuclear factor erythroid 2-related factor (Nrf2) and Heme Oxygenase-1 (HO-1) represents a major antioxidant-de...
Antioxidantes/metabolismo,
Antioxidantes/farmacología,
Isquemia Encefálica,
Dexmedetomidina/farmacología,
Hemo Oxigenasa (Desciclizante)/farmacología,
Hemo-Oxigenasa 1/metabolismo,
Hemo-Oxigenasa 1/farmacología,
Ataque Isquémico Transitorio,
Factor 2 Relacionado con NF-E2/metabolismo,
Factor 2 Relacionado con NF-E2/farmacología,
Fármacos Neuroprotectores/farmacología,
Estrés Oxidativo,
Proteína Quinasa C/metabolismo,
Daño por Reperfusión/prevención & control,
Proteína Quinasa C/farmacología
Purpose:
To investigate the role of peptidyl-prolyl cis/trans isomerase 1 (Pin1) on renal ischemia-reperfusion (I/R) injury and underlying mechanism.
Methods:
By establishing the in vitro and in vivo models of renal I/R, the role of Pin1 was explored by using molecular assays.
Results:
In renal I/R, en...
ABSTRACT Introduction Mutations affecting genes involved in oxidative and signaling pathways may be associated with kidney disease in sickle cell anemia. We determined the allele and genotype frequencies of some polymorphisms in the promoter regions of the Heme Oxygenase-1 (HMOX1) [rs2071746 (A > T) ...
OBJECTIVES: Contrast-induced acute kidney injury (CI-AKI) is an important clinical problem that can be aggravated by diabetes mellitus, a major risk factor. However, heme oxygenase-1 (HO-1), a promising therapeutic target, can exert antioxidant effects against CI-AKI. Thus, we investigated the role of HO...
ABSTRACT Purpose: To investigate the protective effect of parecoxib against lung ischemia-reperfusion injury (LIRI) in rats and the mechanism. Methods: Thirty rats were divided into sham-operated, LIRI and LIRI+parecoxib groups. LIRI model (ischemia for 60 min, followed by reperfusion for 120 min) was ...
BACKGROUND: Koelreuteria henryi Dummer is an indigenous plant in Taiwan. The species has been used in traditional folk medicine for the promotion of liver functions and for treating malaria and urethritis. The present study investigated the antioxidant activity of the flower extract of Koelreuteria henry...
Sapindaceae/química,
Extractos Vegetales/farmacología,
Flores/química,
Antioxidantes/farmacología,
Estrés Oxidativo/efectos de los fármacos,
Peróxido de Hidrógeno,
Flavonoides/análisis,
Apoptosis,
Hemo-Oxigenasa 1,
Factor 2 Relacionado con NF-E2,
Western Blotting,
Caspasa 8
Abstract Purpose To evaluate the neuroprotective effect of L-alanyl-glutamine in a gerbil model of brain ischemia-reperfusion injury based on immunohistochemical quantification of pro-inflammatory and cell activation biomarkers (TNF-α, NF-κB, IL-6 and HO-1). Methods Male gerbils weighing 10...
Abstract Objective We examined the interaction of polymorphisms in the genes heme oxygenase- 1 (HMOX1) and nitric oxide synthase (NOS3) in patients with preeclampsia (PE) as well as the responsiveness to methyldopa and to total antihypertensive therapy. Methods The genes HMOX1 (rs2071746, A/T) and NO...
Abstract Purpose: To investigate the effect of Picroside II on testicular ischemia and reperfusion (l/R) injury and the underlying mechanism. Methods: Sprague-Dawley rats were randomly divided into 4 groups: sham operated group (Sham), Sham with Picroside II treatment group (Sham+ Pic II), l/R group (l...
Apoptosis/efectos de los fármacos,
Western Blotting,
Cinamatos/farmacología,
Hemo-Oxigenasa 1/análisis,
Etiquetado Corte-Fin in Situ,
Glucósidos Iridoides/farmacología,
Malondialdehído/análisis,
NADP/análisis,
Óxido Nítrico/biosíntesis,
Estrés Oxidativo/efectos de los fármacos,
Peroxidasa/análisis,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Daño por Reperfusión/metabolismo,
Daño por Reperfusión/patología,
Daño por Reperfusión/prevención & control,
Testículo/irrigación sanguínea
Li, Hongxia;
Liu, Bofeng;
Gu, Chunyan;
Zeng, Xiao;
Liu, Yali;
Zhang, Susu;
Gong, Haiye;
Shao, Yong;
Yao, Zhenwei;
An, Ruifang.
Abstract Purpose: To investigate the relations of neuropeptide Y (NPY) and heme oxygenase-1 (HO-1) expressions with fetal brain injury in rats with intrahepatic cholestasis of pregnancy (ICP). Methods: Sixty rats pregnant for 15 days were randomly divided into experimental and control groups. The ICP...
Lesiones Encefálicas/etiología,
Lesiones Encefálicas/metabolismo,
Lesiones Encefálicas/patología,
Colestasis Intrahepática/complicaciones,
Colestasis Intrahepática/metabolismo,
Colestasis Intrahepática/patología,
Modelos Animales de Enfermedad,
Hemo-Oxigenasa 1/metabolismo,
Inmunohistoquímica,
Neuropéptido Y/metabolismo,
Complicaciones del Embarazo/metabolismo,
Complicaciones del Embarazo/patología,
Ratas Sprague-Dawley
