Acetylcholinesterase (AChE), hydrolyzes acetylcholine to choline and acetate, thereby terminating this neurotransmitter effect at cholinergic synapses. Therefore, AChE inhibition is used for counterbalance the cholinergic deficit in Alzheimer’s disease (AD) patients. In the ...
Inhibidores de la Colinesterasa/farmacología,
Flavonoides/análisis,
Enfermedad de Alzheimer/tratamiento farmacológico,
Marruecos,
Fenoles/análisis,
Peroxidación de Lípido/efectos de los fármacos,
Antioxidantes/farmacología,
Rumex,
Taraxacum,
Hypericum,
Inhibidores de la Colinesterasa/química,
Antioxidantes/química,
Especies Reactivas de Oxígeno
Costa, Marcus Felipe Bezerra da;
Sampaio, Tiago Lima;
Azevedo, Isabella Evelyn Prado de;
Bandeira, Dânya Lima;
Soares, Igor Lima;
Meneses, Gdayllon Cavalcante;
Ribeiro, Samilly Albuquerque;
Evangelista, Janaina Serra Azul Monteiro;
Bandeira, Mary Anne Medeiros;
Libório, Alexandre Braga;
Martins, Alice Maria Costa.
Abstract Ischemia/reperfusion injury (I/R) is commonly related to acute kidney injury (AKI) and oxidative stress. Antioxidant agents are used to treat this condition. Lippia sidoides is a brazillian shrub with anti-inflammatory and anti-oxidative properties. Thus, the aim of this study is to evaluate the...
Hypericum/efectos adversos,
Lesión Renal Aguda/inducido químicamente,
Isquemia/clasificación,
Antioxidantes/administración & dosificación,
Citometría de Flujo/métodos,
d0183840,
Lesión Renal Aguda/complicaciones,
Macaca mulatta,
Medicina de Hierbas/instrumentación,
d0154240,
d0154270
Abstract Treatment with plant is considered an effective option against increased antibiotic resistance. In this study antibiofilm activity of methanol (CH3OH), chloroform (CHCl3), ethyl acetate (EtOAc) and water (H2O) extracts of Hypericum atomarium Boiss. which is member of Hypericum genus was evaluate...
Hypericum sinaicum L. is an endangered Egyptian medicinal plant of high importance due to the presence of naphthodianthrones (hypericins), which have photodynamic properties and pharmaceutical potential. We sought to assess H. sinaicum ability to develop hairy roots that could be cultured in contained co...
Abstract The aim of this study was to investigate in vitro antioxidant properties and in vivo protective effects of the methanol extract of the Hypericum triquetrifolium Turra (HT) seed against acute hepatotoxicity, myelotoxicity and hematotoxicity in rats induced by cyclophosphamide (CP). In order to i...
Background Hypericum perforatum is used as a medicinal plant, mostly in antidepressant treatment.
With endogenous and exogenous dormancy, more studies about the germination of the seeds are
necessary. Aim: To evaluate the effect of temperature and of preparations of high dilutions on the
germination of s...
Objective: To evaluate the effects of Hypericum perforatum (hypericum) on cognitive behavior and neurotrophic factor levels in the brain of male and female rats. Methods: Male and female Wistar rats were treated with hypericum or water during 28 days by gavage. The animals were then subjected to the ope...
Cognición/efectos de los fármacos,
Relación Dosis-Respuesta a Droga,
Lóbulo Frontal/efectos de los fármacos,
Lóbulo Frontal/metabolismo,
Hipocampo/efectos de los fármacos,
Hipocampo/metabolismo,
Hypericum,
Locomoción/efectos de los fármacos,
Memoria/efectos de los fármacos,
Modelos Animales,
Factores de Crecimiento Nervioso/análisis,
Factores de Crecimiento Nervioso/efectos de los fármacos,
Patrones de Reconocimiento Fisiológico/efectos de los fármacos,
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/farmacología,
Distribución Aleatoria,
Ratas Wistar,
Factores Sexuales,
Resultado del Tratamiento
Introducción: el género Hypericum se caracteriza por poseer gran importancia etnobotánica en diferentes culturas a nivel mundial lo cual ha impulsado los estudios para el aislamiento e identificación de metabolitos bioactivos. Objetivo: realizar la caracterización fitoquímica preliminar y el estudi...
Vecchia, Débora Dalla;
Schamne, Marissa Giovanna;
Ferro, Marcelo Machado;
Santos, Ana Flávia Chaves dos;
Latyki, Camila Lupepsa;
Lara, Danilo Vieira de;
Ben, Juliana;
Moreira, Eduardo Luiz;
Prediger, Rui Daniel;
Miyoshi, Edmar.
Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by the slow and progressive death of dopaminergic neurons in the (substantia nigra pars compact). Hypericum perforatum (H. perforatum) is a plant widely used as an antidepressant, that also presents antioxidant and anti-i...
Thymus vulgaris (Tomillo) e Hypericum perforatum (Hierba de San Juan), plantas originarias de Europa, Asia y África del Norte, han sido utilizadas extensamente en afecciones respiratorias y trastornos depresivos, respectivamente. Dado el potencial terapéutico de estas especies y considerando que todas ...
