León Quiroz, Kevin;
Marín Palma, Damariz;
Gallego Quintero, Salomón;
Yepes Echeverri, Aura Cristina;
Vélez Molina, Jhonatan Darío;
Castro, Gustavo A;
Jaimes, Fabián;
Taborda Vanegas, Natalia Andrea;
Rugeles, María Teresa;
Hernández, Juan C.
Introducción. La infección por el HIV-1 induce un estado de inflamación crónico en el que participan los inflamasomas. El incremento de los parámetros inflamatorios es mayor en individuos con replicación viral activa que en aquellos con control de la replicación viral. Este proceso desencadena alt...
Purpose:
Abnormal activation of NOD-like receptor protein 3 (NLRP3) inflammasome can lead to the occurrence and progression of acute pancreatitis. This study investigated the protective effect of MCC950 on pancreatitis mice.
Methods:
Eighteen mice were randomly divided into control group, severe acute p...
ABSTRACT Purpose: Diabetic retinopathy is currently considered a chronic inflammatory disease involving NOD-like receptor family pyrin domain containing 3 inflammasome activation and retinal microglial pyroptosis. In this study, we aimed to investigate whether NOD-like receptor family pyrin domain conta...
Mendes, Ana Luisa Gomes;
Joaquim, Heloísa Di Matteo;
Zamae, Mara Inês Stefanini;
Assis, Ramon Meira;
Peixoto, Jéssica Renata de Moura;
de Araújo, Margarida Maria Gomes;
Guedes, Antônio Carlos Martins;
Oliveira, Edward José;
Magalhães, Vanessa Peruhype;
Pascoal-Xavier, Marcelo Antônio.
BACKGROUND Leprosy is an infectious-contagious disease caused by Mycobacterium leprae that remain endemic in 105 countries. This neglected disease has a wide range of clinical and histopathological manifestations that are related to the host inflammatory and immune responses. More recently, the inflamma...
Acne is a kind of common, chronic skin condition caused by the inflammation of the sebaceous glands in hair follicles. Recent studies have demonstrated that baicalin (BA) possesses potential anti-inflammatory properties. In this study, we evaluated the anti-inflammatory activity of BA in vitro and in viv...
Dermatitis/tratamiento farmacológico,
Flavonoides,
Inflamasomas,
Inflamación/inducido químicamente,
Inflamación/tratamiento farmacológico,
Interleucina-1beta/metabolismo,
Sistema de Señalización de MAP Quinasas,
FN-kappa B/metabolismo,
Proteína con Dominio Pirina 3 de la Familia NLR,
Propionibacterium acnes/metabolismo,
Ratas Sprague-Dawley,
Transducción de Señal
Metabolic syndrome (MS) is a serious health problem worldwide; it is characterized by a group of metabolic disorders, including central obesity, insulin resistance/type 2 diabetes, hyperlipidemia with accelerated atherosclerosis, hypertension, non-alcoholic fatty liver disease, and elevated uric acid wit...
Resumen Introducción : los inflamasomas dirigen la maduración de las citoquinas IL-1b e IL-18, las cuales contribuyen en la patogénesis de la infección por VIH-1. Dada la complejidad de la infección, se hace necesaria la búsqueda de marcadores que permitan identificar nuevos blancos terapéuticos ...
The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is the most frequently studied in the central nervous system and has been linked to neuropathic pain. In this study, a post-translational mechanism of microRNA (miR)-186 via regulating the expression of NLRP3 in the complete Freu...
Western Blotting,
Modelos Animales de Enfermedad,
Ensayo de Inmunoadsorción Enzimática,
Adyuvante de Freund,
Estudios de Asociación Genética,
Inflamasomas/análisis,
Inflamasomas/fisiología,
Interleucina-18/análisis,
Interleucina-18/metabolismo,
Interleucina-1beta/análisis,
Interleucina-1beta/metabolismo,
Luciferasas,
Ratones Endogámicos C57BL,
MicroARNs/farmacología,
Análisis por Micromatrices,
Proteína con Dominio Pirina 3 de la Familia NLR/análisis,
Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo,
Distribución Aleatoria,
Valores de Referencia,
Factores de Tiempo,
Neuralgia del Trigémino/tratamiento farmacológico
ABSTRACT Objective To determine if considering inflammasome NLRP3 as a treatment option for kidney disease is possible. Methods Literature review related to NLRP3 inflammasome structure, biological function and relationship with renal disease and others (hypertension, diabetes, gout, atherosclerosis,...
Abstract: Inflammasomes are intracellular multiprotein complexes that comprise part of the innate immune response. Since their definition, inflammasome disorders have been linked to an increasing number of diseases. Autoinflammatory diseases refer to disorders in which local factors lead to the activatio...
