A doença de Crohn é uma patologia caracterizada pela inflamação transmural do trato gastrointestinal, compondo o espectro
das doenças inflamatórias intestinais. Nos casos mais graves,
dispõe de tratamento com uso de agentes biológicos e imunomoduladores que podem à reativação ou exacerbaçã...
La terapia con fármacos antagonistas del factor de necrosis tumoral alfa ha sido beneficiosa en el tratamiento de varias enfermedades como las del tejido conectivo e inflamatorias del intestino, pero no está exenta de riesgos. Las principales complicaciones de estas drogas inmunosupresoras son las infe...
Abstract As the treatment of infectious and parasitic diseases improved, the prevalence of these conditions declined. However, with the expansion of the use of immunobiologicals, opportunistic infections have emerged, especially under atypical presentations. The present study reports the case of a patien...
As doenças inflamatórias intestinais (DIIs) são enfermidades crônicas desencadeadas por grave inflamação no trato gastrointestinal. Entre os mediadores imunes envolvidos na patogênese das DIIs, o fator de necrose tumoral alfa (TNF-α) e sugerido como citocina primordial. Assim, ferramentas de inat...
Abstract Biological therapies, including anti-TNF agents, are important in the treatment of various chronic inflammatory diseases, including psoriasis, rheumatoid arthritis or inflammatory bowel disease. The increased use of these drugs translates into an increasing awareness of its adverse effects, whic...
Abstract Paracoccidioidomycosis is an endemic disease in Latin America that is rarely associated with immunosuppression and biological therapy. Herein, we report for the first time a case of pulmonary paracoccidioidomycosis reactivation after infliximab treatment. A 47-year-old man from Brazil received i...
ABSTRACT BACKGROUND: Infliximab and adalimumab are considered effective drugs in the management of Crohn's disease. However, due to significant immunossupression, they can cause important adverse events, mostly infections. OBJECTIVE: The aim of this study was to quantify and describe adverse events d...
Adalimumab/efectos adversos,
Adalimumab/uso terapéutico,
Antiinflamatorios/efectos adversos,
Antiinflamatorios/uso terapéutico,
Enfermedad de Crohn/tratamiento farmacológico,
Fármacos Gastrointestinales/efectos adversos,
Fármacos Gastrointestinales/uso terapéutico,
Infliximab/efectos adversos,
Infliximab/uso terapéutico,
Estudios Longitudinales,
Estudios Retrospectivos,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores
Los fármacos anti factor de necrosis tumoral alfa (TNF-α) bloquean una de las citoquinas implicadas en la patogénesis de la Enfermedad Inflamatoria intestinal (EII). Su uso se relaciona con aumento de tuberculosis (TB), por lo que el despistaje previo es obligatorio. En la infección tuberculosa laten...
Tuberculosis Latente/diagnóstico,
Tuberculosis Latente/tratamiento farmacológico,
Isoniazida/efectos adversos,
Antituberculosos/efectos adversos,
Infliximab/efectos adversos,
Fármacos Gastrointestinales/efectos adversos,
Edema/inducido químicamente,
Erupciones por Medicamentos,
Enfermedad de Crohn/tratamiento farmacológico,
Dermatosis Facial/inducido químicamente,
Exantema/inducido químicamente,
Tuberculosis Latente/inducido químicamente
Primary colorectal lymphoma is a rare form of presentation of gastrointestinal tract lymphomas. Inflammatory bowel disease and its treatment are risk factors for its development. We report a 47-year-old male patient with Ulcerative Colitis of two years of evolution, treated initially with azathioprine an...
Colitis Ulcerosa/tratamiento farmacológico,
Inmunosupresores/efectos adversos,
Linfoma de Células B Grandes Difuso/etiología,
Linfoma de Células B Grandes Difuso/patología,
Neoplasias del Recto/etiología,
Neoplasias del Recto/patología,
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico,
Azatioprina/efectos adversos,
Biopsia,
Ciclofosfamida/administración & dosificación,
Doxorrubicina/administración & dosificación,
Fármacos Gastrointestinales/efectos adversos,
Infliximab/efectos adversos,
Linfoma de Células B Grandes Difuso/diagnóstico por imagen,
Tomografía Computarizada por Tomografía de Emisión de Positrones,
Prednisona/administración & dosificación,
Neoplasias del Recto/diagnóstico por imagen,
Rituximab/administración & dosificación,
Vincristina/administración & dosificación
