Se presenta un estudio observacional compasivo de seguimiento de 20 pacientes portadores de Fibrosis Pulmonar Idiopática tratados con Nintedanib, que muestra que Nintedanib es un medicamento en general bien tolerado, sin efectos adversos serios, que otorga una sobrevida más prolongada que la que cabrí...
O carcinoma epidermóide oral (CEO) é a neoplasia maligna mais frequente da cavidade
oral e constitui um problema de saúde pública devido a sua alta taxa de incidência e
mortalidade devido em muitos casos ao fracasso terapêutico e a resistência tumoral.
Assim sendo, destaca-se a busca por novas mol...
Palhares, Rodrigo Resende;
Britto, Glauco do Canto;
Su, Yun;
Berre, Marie-Aude Le;
Henriques, Ricardo Saad;
Navachi, Fabricio Volpato;
Pereira, Daniela Cristina;
Foli Ostojic, Helene;
Azevedo, Graziella Agostini;
Van Cutsem, Eric.
Introdução: O câncer colorretal (CCR) é o segundo mais incidente e, quando metastático, apresenta taxa de sobrevida de 14% em cinco anos. Regorafenibe é um inibidor de tirosina-quinase (ITQ) aprovado para CCR metastático (CCRm) com aumento comprovado de sobrevida global (SG). Objetivo: Explorar r...
Background: Before the advent of tyrosine kinase inhibitors (TKIs), patients with Philadelphia-positive Acute Lymphoblastic Leukemia (Ph+ALL) had a poor prognosis. The association of TKIs to intensive chemotherapy (CT) improved outcome. Aim: To evaluate results of an intensive CT protocol including TKI i...
Treistman, Natalia;
Nobre, Gabriela Maia;
Tramontin, Mariana Yoshii;
Silva, Gabriel Madeira Werberich da;
Herchenhorn, Daniel;
Araujo, Luiz Henrique de Lima;
Andrade, Fernanda Accioly de;
Corbo, Rossana;
Bulzico, Daniel;
Vaisman, Fernanda.
ABSTRACT Objective: The aim of this study was to describe the real-world experience multikinase inhibitors (MKI) in the treatment advanced differentiated thyroid carcinoma (DTC) refractory to radioactive iodine (RAIR) therapy. Subjects and methods: We reviewed the records of all patients with MKI-treat...
ABSTRACT The concomitant epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) translocations in lung adenocancers are very rare scenarios. Until now, 42 cases described in the literature have all been treated by different drugs. There is no overall consensus regarding the...
Adenocarcinoma/genética,
Neoplasias Pulmonares/genética,
Mutación/genética,
Genes erbB-1/genética,
Exones/genética,
Crizotinib/uso terapéutico,
Inhibidores de Proteínas Quinasas/uso terapéutico,
Docetaxel/uso terapéutico,
Cisplatino/uso terapéutico,
Antineoplásicos/uso terapéutico,
Neoplasias Pulmonares/tratamiento farmacológico,
Adenocarcinoma/tratamiento farmacológico
OBJECTIVES: Lung cancer is the leading cause of cancer-related deaths worldwide. However, factors associated with the survival of patients with advanced non-small-cell lung cancer (NSCLC) who received only hospice care are largely unclear. In this study, we aimed to determine the prognostic factors corre...
Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico,
Carcinoma de Pulmón de Células no Pequeñas/genética,
Carcinoma de Pulmón de Células no Pequeñas/patología,
Receptores ErbB/genética,
Neoplasias Pulmonares/tratamiento farmacológico,
Neoplasias Pulmonares/genética,
Neoplasias Pulmonares/patología,
Mutación,
Estadificación de Neoplasias,
Pronóstico,
Inhibidores de Proteínas Quinasas/uso terapéutico,
Estudios Retrospectivos
Biological therapy dramatically changed the management of Ulcerative Colitis (UC). However, a significant number of these patients fail to respond or have secondary loss of response to this strategy. In this clinical situation, the options include intensification of anti-TNF therapy, the use of a second ...
Cronemberger, Eduardo;
Baldotto, Clarissa;
Marinho, Felipe;
De Marchi, Pedro;
Araújo, Luiz Henrique;
Franke, Fabio;
Salles, Paulo;
Calabrich, Aknar;
Almeida, Thaís;
Custodio, Marcelo Graziano;
Maria, André Santa;
Pereira, Marcelo Horacio;
Castro Jr, Gilberto.
OBJECTIVES: To evaluate the molecular testing and treatment patterns in a retrospective cohort of newly diagnosed treatment-naïve patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC). METHODS: This is an observational retrospective cohort study conducted across 10 cancer cent...
OBJECTIVE: The occurrence of cryptic Philadelphia (Ph) chromosome translocation is rare in BCR-ABL1-positive acute lymphoblastic leukemia (BCR-ABL1+ ALL) and is of unknown significance in the tyrosine kinase inhibitor (TKI) era. METHODS: We retrospectively studied a series of adult patients receiving TK...
