Abstract Changes in metabolite levels of patients using the long-term drug can be comprehensively demonstrated by pharmacometabolomic studies. In this study, biological alterations induced by the administration of solifenacin succinate were investigated with a pharmacometabolomics approach on rat metabol...
ABSTRACT It is part of the omic sciences to search for an understanding of how the cellular system of organisms works as well as studying their biological changes. As part of the omic sciences, we can highlight the genomics whose function is the study of genes, the transcriptomics that studies the change...
Abstract Background Current evidence suggests that upregulation of polyamines system plays a role both in cognitive deficit and synaptic loss observed in Alzheimer's disease (AD). Objective The aim of this study was to determine the plasmatic concentration of polyamines in mild cognitive impairment (...
Poliaminas/sangre,
Disfunción Cognitiva/fisiopatología,
Enfermedad de Alzheimer/fisiopatología,
Cromatografía Liquida/métodos,
Espectrometría de Masas en Tándem/métodos,
Biomarcadores/sangre,
Espermina/sangre,
Metabolómica/métodos,
Poliaminas/metabolismo,
Enfermedad de Alzheimer/diagnóstico,
Disfunción Cognitiva/diagnóstico,
Espermidina/sangre,
Ornitina/sangre,
Putrescina/sangre
Abstract Background Focal segmental glomerulosclerosis (FSGS) is considered one of the most severe glomerular diseases and around 80% of cases are resistant to steroid treatment. Since a large proportion of steroid-resistant (SR) FSGS patients progress to end-stage renal disease, other therapeutic strat...
The prediction or early diagnosis of maternal complications is challenging mostly because the main conditions, such as preeclampsia, preterm birth, fetal growth restriction, and gestational diabetes mellitus, are complex syndromes with multiple underlying mechanisms related to their occurrence. Limited a...
Biomarcadores/metabolismo,
Salud Materna,
Metabolómica/métodos,
Metabolómica/tendencias,
Atención Perinatal,
Complicaciones del Embarazo/diagnóstico,
Complicaciones del Embarazo/metabolismo,
Tercer Trimestre del Embarazo/metabolismo,
Nacimiento Prematuro/diagnóstico,
Pronóstico,
Investigación Biomédica Traslacional/tendencias
OBJECTIVE: This study aims to investigate differences in the metabolomic profiles of patients who received different surgeries for papillary thyroid carcinoma (PTC). METHODS: Two surgical methods, i.e., unilateral and total thyroidectomy, were employed according to different disease conditions. Sera fro...
Abstract: Objective: Inborn errors of metabolism (IEM) are genetic conditions that are sometimes associated with intellectual developmental disorders (IDD). The aim of this study is to contribute to the metabolic characterization of IDD of unknown etiology in Mexico. Materials and methods: Metabolic ...
Abstract: In recent years, the use of high-throughput omics technologies has led to the rapid discovery of many candidate biomarkers. However, few of them have made the transition to the clinic. In this review, the promise of omics technologies to contribute to the process of biomarker development is des...
Abstract: Acute lymphoblastic leukemia (ALL) affects the quality of life of many children in the world and particularly in Mexico, where a high incidence has been reported. With a proper financial investment and with well-organized institutions caring for those patients, together with solid platforms to ...
Abstract An actinobacterial strain VL-RK_09 having potential antimicrobial activities was isolated from a mango orchard in Krishna District, Andhra Pradesh (India) and was identified as Arthrobacter kerguelensis. The strain A. kerguelensis VL-RK_09 exhibited a broad spectrum of in vitro antimicrobial act...
Antiinfecciosos/metabolismo,
Antiinfecciosos/farmacología,
Arthrobacter/aislamiento & purificación,
Arthrobacter/metabolismo,
Mangifera/microbiología,
Antiinfecciosos/química,
Antiinfecciosos/aislamiento & purificación,
Carbono/metabolismo,
Concentración de Iones de Hidrógeno,
Metaboloma,
Metabolómica/métodos,
Pruebas de Sensibilidad Microbiana,
Minerales/metabolismo,
Nitrógeno/metabolismo,
Sales (Química)/metabolismo,
Temperatura
