A doença granulomatosa crônica (DGC) é um erro inato da imunidade de fagócitos, e ocorre em decorrência de mutações que afetam componentes da enzima NADPH oxidase. Os pacientes são suceptíveis a infecções graves e letais por fungos e bactérias. O objetivo deste trabalho é relatar o caso de u...
Tuberculosis,
Terapéutica,
Infecciones Bacterianas,
Enfermedad Granulomatosa Crónica,
Fagocitos,
NADPH Oxidasas,
Infecciones,
Diagnóstico,
Bacterias,
Hongos,
Genética,
Pronóstico,
Sulfametoxazol,
Huesos
A enzima NAD(P)H oxidase (NOX) é a principal fonte de espécies reativas de oxigênio (ERO) no sistema cardiovascular. A produção exacerbada de ERO associada com a redução da capacidade antioxidante pode levar ao estresse oxidativo, que pode causar a hipertensão arterial, principal fator para o des...
ABSTRACT Background: In Philadelphia chromosome-negative myeloproliferative neoplasm (MPN) models, reactive oxygen species (ROS) are elevated and have been implicated in genomic instability, JAK2/STAT signaling amplification, and disease progression. Although the potential effects of ROS on the MPN phen...
Neutrophils play a pivotal role in innate immunity and in the inflammatory response. Neutrophils are very motile cells that are rapidly recruited to the inflammatory site as the body first line of defense. Their bactericidal activity is due to the release into the phagocytic vacuole, called phagosome, of...
Abstract Mucosal epithelial cells act as the first immunologic barrier of organisms, and contact directly with pathogens. Therefore, hosts must have differential strategies to combat pathogens efficiently. Reactive oxygen species (ROS), as a kind of oxidizing agents, participates in the early stage of ki...
Introducción: La enfermedad granulomatosa crónica es una inmunodeficiencia primaria causada por mutaciones en la enzima NADPH oxidasa. Esta compromete la producción de especies reactivas del oxígeno, que son importantes contra patógenos. La prueba de la oxidación de la dihidrorodamina es un método...
Abstract Kiwifruit are a popular fruit worldwide; however, plant growth is threatened by abiotic stresses such as drought and high temperatures. Niacin treatment in plants has been shown to increase NADPH levels, thus enhancing abiotic stresses tolerance. Here, we evaluate the effect of niacin solution s...
BACKGROUND Streptococcus agalactiae can causes sepsis, pneumonia, and meningitis in neonates, the elderly, and immunocompromised patients. Although the virulence properties of S. agalactiae have been partially elucidated, the molecular mechanisms related to reactive oxygen species (ROS) generation in inf...
Abstract Purpose: To investigate the effects of hyperbaric oxygenation (HBO) on intestinal ischemia and reperfusion (IR) injury, we evaluated the expression of 84 genes related to oxidative stress and the antioxidant response in mouse hearts. Methods: Four groups were subjected to 60 minutes of intest...
Expresión Génica,
Oxigenoterapia Hiperbárica/métodos,
Intestinos/irrigación sanguínea,
Estrés Oxidativo/genética,
Daño por Reperfusión/prevención & control,
Antioxidantes/metabolismo,
Antioxidantes/farmacología,
Vasos Coronarios/enzimología,
Modelos Animales de Enfermedad,
Corazón,
Cardiopatías,
Isquemia/metabolismo,
Ratones Endogámicos C57BL,
NADPH Oxidasas/metabolismo,
Estrés Oxidativo/efectos de los fármacos,
Reacción en Cadena de la Polimerasa,
Daño por Reperfusión/metabolismo
The objectives of this study were to characterize Brachyspira hyodysenteriae isolates and to evaluate the antimicrobial susceptibility patterns of strains obtained from pigs in Brazil based on the minimal inhibitory concentration test (MIC). The MIC was performed for 22 B. hyodysenteriae isolates obtaine...
