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Determinantes hereditários do câncer ginecológico e recomendações

Carvalho, Jesus Paula; Carvalho, Filomena Marino; Chami, Anisse Marques; Silva Filho, Agnaldo Lopes da; Primo, Walquíria Quida Salles Pereira.
Femina; 49 (8), 2021
Neoplasias de los Genitales Femeninos/genética, Adenocarcinoma/genética, Neoplasias del Cuello Uterino/genética, Neoplasias Endometriales/genética, Neoplasias Ováricas/genética, Mutación de Línea Germinal/genética, Neoplasias Colorrectales Hereditarias sin Poliposis, Síndrome de Hamartoma Múltiple, Salpingooforectomía, Factores de Riesgo
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Hereditary Breast and Ovarian Cancer Screening Syndrome Profile in Women Diagnosed with Breast Cancer from Paraná State Southwest

Moura, Juliana Batista de; Ghedin, Carla Camila; Takakura, Érika Tomie; Scandolara, Thalita Basso; Rech, Daniel; Panis, Carolina.
Rev. bras. ginecol. obstet; 43 (8), 2021
Abstract Objective This study evaluated the risk of the hereditary breast and ovarian cancer (HBOC) syndrome in patients with breast cancer by using the Family History Screening 7 (FHS-7) tool, a validated low-cost questionnaire with high sensitivity able to screen the HBOC risk in the population. Met...
Neoplasias de la Mama/diagnóstico, Neoplasias de la Mama/genética, Detección Precoz del Cáncer, Predisposición Genética a la Enfermedad, Síndrome de Cáncer de Mama y Ovario Hereditario, Tamizaje Masivo, Neoplasias Ováricas/diagnóstico, Neoplasias Ováricas/genética
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Identification of 5-methylcytosine-related signature for predicting prognosis in ovarian cancer

Wang, Lei; Gao, Song.
Biol. Res; 54 (), 2021
BACKGROUND: Ovarian cancer is one of the most common malignancies often resulting in a poor prognosis. 5-methylcytosine (m5C) is a common epigenetic modification with roles in eukaryotes. However, the expression and function of m5C regulatory factors in ovarian cancer remained unclear. RESULTS: Two molec...
5-Metilcitosina, Neoplasias Ováricas/diagnóstico, Neoplasias Ováricas/genética, Biomarcadores de Tumor/genética, Epigénesis Genética, Regulación Neoplásica de la Expresión Génica
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Prognostic significance of the mad1l1 1673 g:a polymorphism in ovarian adenocarcinomas

Bandala-Jacques, Antonio; Hernández-Cruz, Irwin A.; Castro-Hernández, Clementina; Díaz-Chávez, José; Arriaga-Canon, Cristian; Barquet-Muñoz, Salim A.; Prada-Ortega, Diddier G.; Cantú-de León, David; Herrera, Luis A..
Rev. invest. clín; 72 (6), 2020
Abstract Background: Ovarian cancer is the most lethal gynecologic cancer. Although most patients respond adequately to the first-line therapy, up to 85% experience a recurrence of disease, which carries a poor prognosis. Mitotic arrest deficiency 1 is a protein that helps in the assembly of the mitotic...
Adenocarcinoma/genética, Adenocarcinoma/mortalidad, Proteínas de Ciclo Celular/genética, Neoplasias Ováricas/genética, Neoplasias Ováricas/mortalidad, Polimorfismo de Nucleótido Simple, Pronóstico, Estudios Retrospectivos, Tasa de Supervivencia
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Knockdown of long non-coding RNA HOTAIR reverses cisplatin resistance of ovarian cancer cells through inhibiting miR-138-5p-regulated EZH2 and SIRT1

Zhang, Yun; Ai, Hao; Fan, Xue; Chen, Suxian; Wang, Yadi; Liu, Lili.
Biol. Res; 53 (), 2020
BACKGROUND: Cisplatin resistance (DDP-resistance) remains one of the major causes of poor prognosis in females with ovarian cancer. Long non-coding RNAs (lncRNAs) have been shown to participate in the regulation of cellular processes, including chemoresistance. The aim of this study was to explore the ro...
Cisplatino/farmacología, Resistencia a Antineoplásicos/genética, Neoplasias Ováricas/genética, ARN Largo no Codificante/genética, Apoptosis/efectos de los fármacos, Proteína Potenciadora del Homólogo Zeste 2/antagonistas & inhibidores, Regulación Neoplásica de la Expresión Génica/efectos de los fármacos, Técnicas de Inactivación de Genes/métodos, MicroARNs/antagonistas & inhibidores, Sirtuina 1/antagonistas & inhibidores, Línea Celular Tumoral, Reacción en Cadena en Tiempo Real de la Polimerasa, Regulación hacia Arriba
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Overexpression of long noncoding RNA PTPRG-AS1 is associated with poor prognosis in epithelial ovarian cancer

Ren, Xue-Ying; Yang, Wei-Bin; Tian, Yun.
Rev Assoc Med Bras (1992); 66 (7), 2020
SUMMARY OBJECTIVE Long noncoding RNAs (lncRNAs) have been shown to play a critical role in tumor progression. Abnormal expression of LncRNA PTPRG antisense RNA 1 (PTPRG-AS1) has been reported in several tumors. Hence, we aimed to determine the expression and clinical significance of PTPRG-AS1 in epithe...
Carcinoma Epitelial de Ovario/genética, Regulación Neoplásica de la Expresión Génica, Neoplasias Ováricas/genética, Pronóstico, ARN Largo no Codificante, Proteínas Tirosina Fosfatasas Clase 5 Similares a Receptores/genética
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LncRNA OIP5-AS1 upregulates snail expression by sponging miR-34a to promote ovarian carcinoma cell invasion and migration

Jiang, Xingzhi; Ye, Zhongxue; Jiang, Yafen; Yu, Wen; Fang, Qian.
Biol. Res; 53 (), 2020
BACKGROUND: Although OIP5-AS1 has been characterized as an oncogenic lncRNA in many types of cancer, its role and underlying mechanism in ovarian carcinoma (OC) remains unknown. This study aimed to investigate the role of OIP5-AS1 in OC. METHODS: OC tissues and non-tumor tissues (ovary tissues within 3 c...
MicroARNs/genética, MicroARNs/metabolismo, Neoplasias Ováricas/genética, Neoplasias Ováricas/patología, ARN Largo no Codificante/genética, ARN Largo no Codificante/fisiología, Proliferación Celular, Regulación Neoplásica de la Expresión Génica, Invasividad Neoplásica
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Mir-30b-3p affects the migration and invasion function of ovarian cancer cells by targeting the CTHRC1 gene

Li, Yan; Zhou, Jinhua; Wang, Juan; Chen, Xiaoping; Zhu, Yan; Chen, Youguo.
Biol. Res; 53 (), 2020
BACKGROUND: The aim of this study was to investigate the effect role and mechanism of miR-30b-3p on ovarian cancer cells biological function. METHODS: The expression of miR-30b-3p was detected in ovarian cancer cell lines and normal ovarian epithelial cell line by qRT-PCR. Mir-30b-3p mimic was transfecte...
Transición Epitelial-Mesenquimal/genética, Proteínas de la Matriz Extracelular/genética, Regulación Neoplásica de la Expresión Génica/genética, MicroARNs/genética, Neoplasias Ováricas/genética, Proteínas de la Matriz Extracelular/metabolismo, Neoplasias Ováricas/metabolismo, Apoptosis, Línea Celular Tumoral, Movimiento Celular, Proliferación Celular, Invasividad Neoplásica, Transducción de Señal
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Recomendación de la utilización de herramientas de evaluación de riesgo familiar para el cáncer relacionado con mutaciones de los genes BRCA 1/2 en atención primaria
The USPSTF recommends the use of family risk assessment tools in primary care for cancer related to BRCA gene mutations 1/2

Avendaño, Yanina Edith.
Evid. actual. práct. ambul; 22 (3), 2019
Neoplasias de la Mama/genética, Neoplasias de la Mama/prevención & control, Neoplasias de las Trompas Uterinas/genética, Genes BRCA1, Genes BRCA2, Asesoramiento Genético, Predisposición Genética a la Enfermedad, Pruebas Genéticas, Mutación, Neoplasias Ováricas/genética, Neoplasias Ováricas/prevención & control, Neoplasias Peritoneales/genética, Medición de Riesgo
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