Abstract Only few studies have focus on animals that received Pilocarpine (Pilo) and did not develop behavioral status epilepticus (SE) and, whether they may become epileptic in the model's chronic phase. Previews works observed mossy fiber sprouting in the hippocampus of Non-SE (NSE) rats, while others ...
ABSTRACT Purpose: To investigate the effects of pharmacological accommodation and cycloplegia on ocular measurements. Methods: Thirty-three healthy subjects [mean (±SD) age, 32.97 (±5.21) years] volunteered to participate in the study. Measurement of the axial length, macular and choroidal thickness,...
Abstract Background Adenosine A1 receptor (AA1R) is widely present in the central nervous system, exerting brain protective antiepileptic effects, mainly by binding corresponding G proteins. We evaluated the neuroprotective effects of AA1R on hippocampal neuronal injury after lithium chloride-pilocarpin...
Agonistas del Receptor de Adenosina A1/farmacología,
Apoptosis/efectos de los fármacos,
Modelos Animales de Enfermedad,
Epilepsia/tratamiento farmacológico,
Hipocampo/efectos de los fármacos,
Hipocampo/patología,
Cloruro de Litio/toxicidad,
Neuronas/patología,
Fármacos Neuroprotectores/farmacología,
Pilocarpina/toxicidad,
Ratas Sprague-Dawley,
Factores de Tiempo
Resumo Objetivo: Avaliar modificações de acuidade visual, refração, campo visual e diâmetro pupilar, em pacientes pseudofácicos, após a instilação de pilocarpina a 2%. Métodos: Ensaio clínico, controlado, mascarado e randomizado realizado entre maio de 2015 e setembro de 2016 no Hospital Uni...
Facoemulsificación/métodos,
Lentes Intraoculares,
Seudofaquia,
Errores de Refracción/tratamiento farmacológico,
Agudeza Visual,
Refracción Ocular,
Pruebas del Campo Visual,
Pupila/fisiología,
Pilocarpina/farmacología,
Pilocarpina/administración & dosificación,
Administración Oftálmica,
Implantación de Lentes Intraoculares,
Facoemulsificación/efectos adversos,
Errores de Refracción/etiología
ABSTRACT Purpose: We investigated parasympathetic innervation abnormalities of the iris sphincter and ciliary muscles in chronic Chagas disease by measuring pupillary diameter and intraocular pressure. Methods: A group of 80 patients with Chagas disease was compared with 76 healthy individuals without ...
Anisocoria/diagnóstico,
Anisocoria/etiología,
Anisocoria/fisiopatología,
Estudios de Casos y Controles,
Enfermedad de Chagas/complicaciones,
Enfermedad de Chagas/fisiopatología,
Estudios Transversales,
Presión Intraocular/fisiología,
Mióticos/farmacología,
Pilocarpina/farmacología,
Reflejo Pupilar/efectos de los fármacos,
Reflejo Pupilar/fisiología
Xerostomia or dry mouth is one of the most common and disturbing adverse effects following radiotherapy for head and neck cancer (HNC). This complication strongly increases the risk for dental caries, difficulties with chewing, swallowing and sleep disorders with significant impact on patients’ quality...
Abstract The aim of this study was to assess the activity of aqueous (AE) and ethanolic extracts (EE) and pilocarpine hydrochloride, which were extracted and isolated from Pilocarpus microphyllus (Jaborandi), respectively, on Rhipicephalus (Boophilus) microplus. High performance liquid chromatography (HP...
Pupil abnormalities in leprosy usually result from chronic iritis with loss of stroma, iris miosis, a sluggish reaction to light, and poor dilation in response to anticholinergic mydriatics. We report two patients with long-standing lepromatous leprosy who developed tonic pupils characterized by mydriasi...
A Síndrome de Urrets-Zavalia apresenta achados oculares bem descritos, porém sua fisiopatologia ainda é incerta. A isquemia iriana é o mecanismo proposto mais comum. Descrevemos dois casos submetidos à ceratoplastia lamelar profunda (CLP) realizadas pelo mesmo cirugião que desenvolveram a síndrome...
Queratocono/diagnóstico,
Queratocono/cirugía,
Opacidad de la Córnea/diagnóstico,
Opacidad de la Córnea/cirugía,
Trasplante de Córnea/efectos adversos,
Trasplante de Córnea/métodos,
Iris/patología,
Pupila/fisiología,
Midriasis/etiología,
Midriasis/diagnóstico,
Midriasis/tratamiento farmacológico,
Lámina Limitante Posterior/patología,
Atrofia,
Isquemia,
Enfermedades del Iris/diagnóstico,
Enfermedades del Iris/etiología,
Síndrome,
Pilocarpina/administración & dosificación,
Pilocarpina/uso terapéutico
OBJETIVO: O objetivo desse estudo foi caracterizar a neuroproteção do RPia em ratos submetidos ao status epilepticus (SE) induzido pela pilocarpina (Pilo). MÉTODOS: Avaliou-se o balanço entre utilização local da glicose cerebral (ULGC) e fluxo sanguíneo cerebral local (FSCL) após 4 horas de SE, e...
