Lee, Wonhwa;
Kim, Ji-Eun;
Yang, Sumin;
Lee, Bong-Seon;
Cho, Soo-Hyun;
Lee, Jee-Hyun;
Choi, Ga-Eun;
Park, Eui Kyun;
Song, Gyu-Yong;
Bae, Jong-Sup.
Abstract RGX-365 is the main fraction of black ginseng conmprising protopanaxatriol (PPT)-type rare ginsenosides (ginsenosides Rg4, Rg6, Rh4, Rh1, and Rg2). No studies on the antiseptic activity of RGX-365 have been reported. High mobility group box 1 (HMGB1) is recognized as a late mediator of sepsis, a...
Abstract In China, Scutellaria is used for treating inflammatory-related diseases. Baicalin is the main active component of Scutellaria and has protective effects on acute pancreatitis. However, the mechanism of Baicalin is still unclear. In this study, the protective effects of baicalin on acute pancrea...
SUMMARY OBJECTIVE: To investigate the associations of high-mobility group box 1 and its specific receptor, receptor for advanced glycation end products with acute lung injury in patients with acute aortic dissection. METHODS: A total of 96 acute aortic dissection patients were divided into acute aortic...
ABSTRACT Introduction: The high mobility group box 1 proteins (HMGB1) are non-histone nuclear proteins reported to be present at high levels in some autoimmune diseases, such as systemic lupus erythematosus (SLE). Likewise, in contrast to healthy individuals, patients with SLE have a higher prevalence ...
Nugraha, Alexander Patera;
Narmada, Ida Bagus;
Sitasari, Putri Intan;
Inayati, Fidiyah;
Wira, Rahendra;
Triwardhani, Ari;
Hamid, Thalca;
Ardani, I Gusti Aju Wahju;
Djaharu'ddin, Irwadi;
Rahmawati, Dwi;
Iskandar, Regina Purnama Dewi.
Abstract Objective: To investigate the expression of High Mobility Group Box 1 (HMGB1) and Heat Shock Protein-70 (HSP-70) during orthodontic tooth movement (OTM) after (-)- Epigallocatechin-3-Gallate (EGCG) in East Java Green Tea (Camelia Sinensis) Methanolic Extract (GTME) administration in vivo. Mate...
Análisis de Varianza,
Técnicas de Movimiento Dental/instrumentación,
Proteínas de Choque Térmico,
Proteína HMGB1,
Ratas Wistar,
Diente Molar,
Modelos Animales,
Indonesia,
Inmunohistoquímica,
Incisivo,
Antioxidantes/uso terapéutico,
Té,
Huesos
This study aimed to investigate the association of serum high-mobility group box-1 (HMGB1) and toll-like receptor 4 (TLR4) expressions with the risk of epilepsy as well as their correlations with disease severity and resistance to anti-epilepsy drugs. One hundred and five epilepsy patients and 100 health...
OBJECTIVES: To investigate the relationship between the serum levels of NLRP3 and HMGB-1 and the prognosis of patients with severe blunt abdominal trauma. METHODS: In total, 299 patients were included in the current study from July 2014 to December 2015. All patients were divided into the mild/moderate ...
Although Taxol has improved the survival of cancer patients as a first-line chemotherapeutic agent, an increasing number of patients develop resistance to Taxol after prolonged treatment. The potential mechanisms of cancer cell resistance to Taxol are not completely clear. It has been reported that micro...
Antineoplásicos Fitogénicos/metabolismo,
Antineoplásicos Fitogénicos/uso terapéutico,
Apoptosis/genética,
Autofagia/genética,
Neoplasias de la Mama/tratamiento farmacológico,
Neoplasias de la Mama/genética,
Neoplasias de la Mama/metabolismo,
Resistencia a Antineoplásicos/genética,
Regulación Neoplásica de la Expresión Génica/genética,
Proteína HMGB1/genética,
Proteína HMGB1/metabolismo,
Células MCF-7/metabolismo,
MicroARNs/genética,
MicroARNs/metabolismo,
Paclitaxel/metabolismo,
Paclitaxel/uso terapéutico,
Regulación hacia Arriba/genética
Glucocorticoid insensitivity is an important barrier to the treatment of several inflammatory diseases, including acute lung injury (ALI). Saquinavir (SQV) is an inhibitor of the human immunodeficiency virus protease, and the therapeutic effects of SQV in ALI accompanied with glucocorticoid insensitivity...
Lesión Pulmonar Aguda/inducido químicamente,
Lesión Pulmonar Aguda/tratamiento farmacológico,
Antígenos CD/efectos de los fármacos,
Antígenos CD/metabolismo,
Cadherinas/efectos de los fármacos,
Cadherinas/metabolismo,
Modelos Animales de Enfermedad,
Proteína HMGB1/efectos de los fármacos,
Proteína HMGB1/metabolismo,
Lipopolisacáridos,
Metilprednisolona/administración & dosificación,
Ratas Sprague-Dawley,
Saquinavir/administración & dosificación,
Transducción de Señal/efectos de los fármacos,
Receptor Toll-Like 4/efectos de los fármacos,
Receptor Toll-Like 4/metabolismo
Abstract INTRODUCTION Renal damage is a consequence of severe malaria, and is generally caused by sequestration of Plasmodium falciparum -infected erythrocytes in the renal microcirculation, which leads to obstruction, hypoxia, and ischemia. This triggers high mobility group box 1 (HMGB1) to send a dang...
Lesión Renal Aguda/parasitología,
Modelos Animales de Enfermedad,
Proteína HMGB1/metabolismo,
Proteínas HSP70 de Choque Térmico/metabolismo,
Malaria/complicaciones,
Malaria/metabolismo,
Ratones,
Ratones Endogámicos C57BL,
Óxido Nítrico Sintasa de Tipo II/metabolismo,
Índice de Severidad de la Enfermedad,
Tirosina/antagonistas & inhibidores,
Tirosina/metabolismo
