BACKGROUND: Duchenne muscular dystrophy (DMD) is an X-linked lethal genetic disorder for which there is no effective treatment. Previous studies have shown that stem cell transplantation into mdx mice can promote muscle regeneration and improve muscle function, however, the specific molecular mechanisms ...
Diabetes mellitus is a metabolic disorder affecting a great part of population around the world. It is the fifth leading death causing disease in the world and its cases are increasing day by day. Traditional medicine is thought to have promising future in the treatment of diabetes mellitus. In contrast ...
Fitoquímicos/análisis,
Alcaloides/análisis,
Diabetes Mellitus/patología,
Esteroles/efectos adversos,
Glucosa-6-Fosfatasa/efectos adversos,
Drogas Sintéticas,
Metabolismo,
Plantas Medicinales/anatomía & histología,
Preparaciones Farmacéuticas,
Productos Biológicos,
Proteínas Quinasas Activadas por AMP
Troncoso, Mayarling Francisca;
Pavez, Mario;
Wilson, Carlos;
Lagos, Daniel;
Duran, Javier;
Ramos, Sebastián;
Barrientos, Genaro;
Silva, Patricio;
Llanos, Paola;
Basualto-Alarcón, Carla;
Westenbrink, B. Daan;
Lavandero, Sergio;
Estrada, Manuel.
BACKGROUND: Testosterone regulates nutrient and energy balance to maintain protein synthesis and metabolism in cardiomyocytes, but supraphysiological concentrations induce cardiac hypertrophy. Previously, we determined that testosterone increased glucose uptake—via AMP-activated protein kinase (AMPK)...
Lima, R P de;
Nunes, P I G;
Viana, A F S C;
Oliveira, F T B de;
Silva, R A C;
Alves, A P N N;
Viana, D A;
Fonseca, S G C;
Carvalho, A A;
Chaves, M H;
Rao, V S;
Santos, F A.
Nonalcoholic fatty liver disease (NAFLD), characterized by hepatosteatosis and steatohepatitis, is intrinsically related to obesity. Our previous study reported on the anti-obese activity of α,β-amyrin (AMY), a pentacyclic triterpene isolated from Protium heptaphyllum. This study investigated i...
SUMMARY OBJECTIVE: This study was to assess the genetic association of copy number variations in two genes (PRKAB2 and PPM1K) located in two regions (tetralogy of Fallot and ventricular septal defect) in a Chinese Han population. METHODS: A total of 200 congenital heart disease patients (100 tetralogy ...
Abstract Purpose: To investigate the specific molecular mechanisms and effects of curcumin derivative J147 on diabetic peripheral neuropathy (DPN). Methods: We constructed streptozotocin (STZ)-induced DPN rat models to detected mechanical withdrawal threshold (MWT) in vivo using Von Frey filaments. I...
Proteínas Quinasas Activadas por AMP/análisis,
Proteínas Quinasas Activadas por AMP/efectos de los fármacos,
Apoptosis/efectos de los fármacos,
Western Blotting,
Calcio/análisis,
Supervivencia Celular/efectos de los fármacos,
Células Cultivadas,
Curcumina/análogos & derivados,
Curcumina/farmacología,
Diabetes Mellitus Experimental/complicaciones,
Diabetes Mellitus Experimental/metabolismo,
Neuropatías Diabéticas/tratamiento farmacológico,
Neuropatías Diabéticas/metabolismo,
Microscopía Fluorescente,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Reproducibilidad de los Resultados,
Estreptozocina,
Canal Catiónico TRPA1/análisis,
Canal Catiónico TRPA1/efectos de los fármacos,
Factores de Tiempo
RESUMEN Introducción: la metformina es una biguanida que disminuye gluconeogénesis e incrementa la recaptación de glucosa en los músculos, sin embargo, más allá del glucémico se han documentado beneficios adicionales como la disminución de complicaciones crónicas derivadas de la hiperglucemia,...
Resumo: A AMP-activated protein kinase (AMPK) regula o balanço energético por ações no hipotálamo. Sua ativação está ligada ao aumento da ingestão alimentar e sua inibição leva a redução da ingestão alimentar. Recentes evidências demonstram que outras regiões do sistema nervoso podem cont...
ABSTRACT Objective: Studies have indicated that AMPK play critical roles in the regulation of innate immunity and inflammatory responses. However, the role of the polymorphisms of PRKAA1 gene in immune-response to infectious organisms remains unknown. To evaluate the potential role of PRKAA1/AMPKα1...
