SUMMARY: The Wnt pathway is essential for the initiation of lizard tail regeneration. The regenerated lizard tails exhibit obvious morphological differences compared to the original ones. The expression of Wnt1 and Wnt2b proteins in the regenerating tail of Scincella tsinlingensis was detected by immunoh...
Antecedentes: Las células madres intestinales generan las distintas estirpes celulares a dicho nivel. Estas se regulan por interacciones entre el epitelio y las células del nicho celular anexo. Estas se pueden ver dañadas en tratamientos con radiación, generando el síndrome gastrointestinal inducido...
In order to compare Wnt/ beta-catenin expression in mouse and chick facial primordia during development, we performed an immunohistochemical analysis of both protein expressions in E12 to E17 mouse embryos and in E3 and E10 chick embryos. During odontogenesis, from bud to bell stage, both proteins exhibi...
Yogui, Fernanda Costa;
Momesso, Gustavo Antonio Correa;
Faverani, Leonardo Perez;
Polo, Tarik Ocon Braga;
Ramalho-Ferreira, Gabriel;
Hassumi, Jaqueline Suemi;
Rossi, Ana Cláudia;
Freire, Alexandre Rodrigues;
Prado, Felippe Bevilacqua;
Okamoto, Roberta.
Abstract Raloxifene is an antiresorptive drug, selective estrogen receptor modulator (SERM) used in the treatment of osteoporosis. Objective To evaluate proteins related to bone repair at the peri-implant bone in a rat model of osteoporosis treated with raloxifene. Material and Methods 72 rats were div...
Subunidad alfa 1 del Factor de Unión al Sitio Principal/análisis,
Subunidad alfa 1 del Factor de Unión al Sitio Principal/efectos de los fármacos,
Modelos Animales de Enfermedad,
Expresión Génica,
Inmunohistoquímica,
Osteoblastos/efectos de los fármacos,
Osteocalcina/análisis,
Osteocalcina/efectos de los fármacos,
Osteogénesis/efectos de los fármacos,
Osteopontina/análisis,
Osteopontina/efectos de los fármacos,
Osteoporosis/tratamiento farmacológico,
Osteoporosis/patología,
Ovariectomía,
Reacción en Cadena de la Polimerasa,
Proteínas/análisis,
Proteínas/efectos de los fármacos,
Clorhidrato de Raloxifeno/farmacología,
Ratas Wistar,
Valores de Referencia,
Reproducibilidad de los Resultados,
Moduladores Selectivos de los Receptores de Estrógeno/farmacología,
Factores de Tiempo,
Resultado del Tratamiento,
Proteínas Wnt/análisis,
Proteínas Wnt/efectos de los fármacos,
Microtomografía por Rayos X,
beta Catenina/análisis,
beta Catenina/efectos de los fármacos
ABSTRACT Background: Gastric cancer is the fifth most frequent cancer and the third most common cause of cancer-related deaths worldwide.It has been reported that Wnt/ betacatenin pathway is activated in 30-50% of these tumors. However,the deregulation of this pathway has not been fully elucidated. Ai...
Adenocarcinoma/metabolismo,
Proteína de la Poliposis Adenomatosa del Colon/biosíntesis,
Antígenos CD,
Factores de Transcripción Básicos con Cremalleras de Leucinas y Motivos Hélice-Asa-Hélice/biosíntesis,
Cadherinas/biosíntesis,
Proteínas Inhibidoras de la Apoptosis/biosíntesis,
Neoplasias Gástricas/metabolismo,
Survivin,
Factor de Transcripción 4,
Factores de Transcripción/biosíntesis,
Proteínas Wnt/biosíntesis,
Vía de Señalización Wnt
Background: WNT4 is a protein that plays a crucial role in ovarian differentiation and development in mammals, with a relatively well understood function in mammalian gonadal differentiation. The role of WNT4 in teleost fish; however, remains unclear. In the present study, cDNAs of Wnt4a and Wnt4b were c...
BACKGROUND: Wnt-5a is a member of the WNT family of secreted lipoglycoproteins, whose expression increases during development; moreover, Wnt-5a plays a key role in synaptic structure and function in the adult nervous system. However, the mechanism underlying these effects is still elusive. MicroRNAs (miR...
Ciclooxigenasa 2/análisis,
Hipocampo/enzimología,
MicroARNs/fisiología,
Neuronas/enzimología,
Proteínas Wnt/fisiología,
Hipocampo/química,
Neuronas/química,
Western Blotting,
Células Cultivadas,
Regulación hacia Abajo,
Expresión Génica,
Perfilación de la Expresión Génica,
Marcación de Gen,
Plasticidad Neuronal,
Ratas Sprague-Dawley,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Proteína Wnt-5a
Colorectal cancer is linked to several signaling pathways such as Wnt pathway. Our objective is to detect and verify the integrity of protein members of Wnt signaling pathway in colorectal carcinoma and non-neoplastic colorectal tissue. Sixty-four patients with colorectal carcinoma provided samples of co...
Alterações na expressão das proteínas Wnt no carcinoma espinocelular bucal, permitiram a construção de hipóteses sobre o papel da Wnt-5a em desordens potencialmente malignas. Objetivo: Avaliar a expressão imuno-histoquímica da proteína Wnt-5a em displasias epiteliais bucais. Metodologia: Foram ...
BACKGROUND: activation of the Wnt pathway by mutated APC gene is considered the initial event in colorectal carcinogenesis. The identification of these mutations can improve the specific treatment of the adenocarcinoma. OBJECTIVE: detect and evaluate wild-type APC protein in tissue from colorectal adenom...
